부산대학교 도서관

Background Maternal exposure to ambient air pollution affects placental growth markers. Objectives Investigate impact of household air pollution (HAP) on placental growth markers. Methods Two groups of pregnant women were identified: firewood/kerosene stove-users (A, n = 33) and bioethanol stove-users (B, n = 44) that participated in a randomized control trial in Ibadan, Nigeria. A third group of non-smoking and presumed liquefied petroleum gas-using Chicago women (C, n = 19) were included in this exploratory pilot to assess for possible differences between similar racial groups. Levels of placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) were measured in maternal and cord plasma using ELISA. Results Maternal and cord blood sFlt-1 and PlGF did not differ significantly between women of groups A and B. Nevertheless, both groups differed significantly from the Chicago group in that group A women had lower maternal sFlt-1 (1372.50 vs. 3194.19) but higher PlGF (1607.87 vs. 442.80), and higher cord blood sFlt-1 (2925.02 vs. 107.53) and PlGF (223.68 vs. 6.92), all p ≤ 0.001. Group B showed similar trends (all p ≤ 0.002). Maternal PlGF levels were positively correlated to minutes of HAP exposure when PM 2.5 concentration was above 100 μg/m 3 in Nigerian women. Conclusions Maternal levels of PlGF and cord blood levels of sFlt-1 and PlGF in Nigerian women with varying HAP exposures were significantly higher than Chicago-based women who had no presumed HAP exposure. It suggests that in-utero exposure to HAP influenced levels of angiogenic factors involved in normal placentation and growth and could represent compensation for pollutants exposure to preserve fetal viability. [ABSTRACT FROM AUTHOR]