학술논문
Proline-Catalyzed Diastereoselective Synthesis of Dihydroquinolinyl-Spirooxindole via Aza-Michael/Aldol Reaction.
Document Type
Article
Source
Subject
*ALDOLS
*CRYSTALS
*NORMAL-phase chromatography
*ORGANIC chemistry
*MOLECULAR structure
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Language
ISSN
0039-7881
Abstract
SP 1 sp H NMR (400 MHz, CDCl SB 3 sb ): = 8.15-8.11 (m, 1 H), 7.83-7.78 (m, 2 H), 7.62-7.48 (m, 4 H), 7.38-7.35 (m, 1 H), 7.34-7.29 (m, 1 H), 7.21-7.12 (m, 5 H), 7.03 (td, I J i = 7.8, 1.1 Hz, 1 H), 6.62 (td, I J i = 7.6, 0.8 Hz, 1 H), 6.32 (s, 1 H), 6.28 (d, I J i = 7.8 Hz, 1 H), 5.37 (d, I J i = 7.5 Hz, 1 H), 4.11 (d, I J i = 9.2 Hz, 1 H), 2.73 (s, 3 H), 1.55 (br s, 1 H). SP 1 sp H NMR (400 MHz, CDCl SB 3 sb ): = 8.14 (dd, I J i = 8.0, 1.0 Hz, 1 H), 7.72-7.67 (m, 2 H), 7.57-7.50 (m, 1 H), 7.40-7.35 (m, 1 H), 7.34-7.28 (m, 3 H), 7.24-7.16 (m, 5 H), 6.57 (dd, I J i = 8.5, 2.6 Hz, 1 H), 6.31 (s, 1 H), 6.19 (d, I J i = 8.5 Hz, 1 H), 4.93 (d, I J i = 2.6 Hz, 1 H), 4.20 (d, I J i = 8.9 Hz, 1 H), 3.36 (s, 3 H), 2.70 (s, 3 H), 2.41 (s, 3 H), 1.56 (d, I J i = 4.9 Hz, 1 H). SP 1 sp H NMR (400 MHz, CDCl SB 3 sb ): = 8.13 (d, I J i = 8.0 Hz, 1 H), 7.71-7.66 (m, 2 H), 7.54 (t, I J i = 7.8 Hz, 1 H), 7.39-7.34 (m, 1 H), 7.33-7.27 (m, 3 H), 7.21-7.13 (m, 5 H), 6.83 (dd, I J i = 7.9, 0.8 Hz, 1 H), 6.31 (s, 1 H), 6.18 (d, I J i = 7.9 Hz, 1 H), 5.13 (s, 1 H), 4.17 (d, I J i = 8.2 Hz, 1 H), 2.70 (s, 3 H), 2.40 (s, 3 H), 1.96 (s, 3 H), 1.52 (d, I J i = 8.0 Hz, 1 H). SP 1 sp H NMR (400 MHz, CDCl SB 3 sb ): = 8.04-8.00 (m, 1 H), 7.55 (d, I J i = 8.3 Hz, 2 H), 7.52-7.48 (m, 1 H), 7.32-7.24 (m, 3 H), 7.21-7.17 (m, 2 H), 6.78 (d, I J i = 7.8 Hz, 1 H), 6.63 (td, I J i = 7.7, 0.9 Hz, 1 H), 5.43-5.39 (m, 2 H), 4.01 (d, I J i = 8.2 Hz, 1 H), 3.25 (s, 3 H), 3.16 (s, 3 H), 2.39 (s, 3 H), 1.76 (d, I J i = 8.2 Hz, 1 H). [Extracted from the article]