학술논문
Garlic And Its Active Metabolite Allicin Produce Endothelium- And Nitric Oxide-Dependent Relaxation In Rat Pulmonary Arteries.
Document Type
Article
Author
Source
Subject
*GARLIC
*ENDOTHELIUM
*NITRIC oxide
*PULMONARY artery
*LABORATORY rats
*PHENYLEPHRINE
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Language
ISSN
0305-1870
Abstract
SUMMARY 1. The aims of the present study were to investigate the effects of fresh garlic and one of its active metabolites, allicin, on rat isolated pulmonary arteries (RPA). 2. In endothelium-intact and phenylephrine-precontracted RPA, the addition of a water or a 5% ethanol extract of fresh garlic (1-500 μg/mL) resulted in a dose-dependent relaxation reaching a maximum (mean±SEM) of -91 ± 3 and -93 ± 2%, respectively, with an ED50 of 113+/-12 and 106+/-10g/mL, respectively. The vasorelaxation was readily reversible upon washing and no tachyphylaxis was noted. [ABSTRACT FROM AUTHOR]