학술논문

Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study.

Document Type

Journal Article

Author

Abheiden, Carolien N. H.; Blomjous, Birgit S.; Kroese, Sylvia J.; Bultink, Irene E. M.; Fritsch-Stork, Ruth D. E.; Lely, A. Titia; de Boer, Marjon A.; de Vries, Johanna I. P.

Source

Hypertension in Pregnancy. Feb2017, Vol. 36 Issue 1, p8-15. 8p.

Subject

*HEPARIN
*ASPIRIN
*SYSTEMIC lupus erythematosus
*PREGNANCY complications
*ANTIPHOSPHOLIPID syndrome
*MOLECULAR weights
*COHORT analysis
*ANTICOAGULANTS
*DATABASES
*HYPERTENSION in pregnancy
*PREMATURE infants
*EVALUATION of medical care
*PREGNANCY
*ENOXAPARIN
*THERAPEUTICS

Language

ISSN

1064-1955

Abstract

Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015.Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001).Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use. [ABSTRACT FROM AUTHOR]

Online Access

EBSCOHost PDF Web of Science JCR 저널정보 Scopus Find it@PNU

이메일

부산대학교 도서관

Online Access

메일 발송