학술논문
The time interval between injection of nicotine and tremor initiation: a new index for evaluating nicotine efficacy in rodents.
Document Type
Article
Author
Source
Subject
*POISONS
*TREMOR
*NICOTINE
*RATS
*RODENTS
*LABORATORY animals
*ANIMAL models in research
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Language
ISSN
1537-6516
Abstract
Tremor is one of the effects of nicotine as a toxic substance, especially in animal models. The intensity and duration of tremors were used to evaluate the effect of nicotine on locomotor activity in laboratory animals. In our observations, the time interval between nicotine injection and the onset of tremor changed depending on the dose. Therefore, by increasing the dose of nicotine in rats, the time interval of tremor onset was also shortened. These results suggest that the time interval between nicotine injection and the onset of tremors can be used as a complementary index for better evaluation of nicotine-derived motor disturbances. [ABSTRACT FROM AUTHOR]