학술논문

Practical aspects of management of recurrent aphthous stomatitis.
Document Type
Article
Source
Journal of the European Academy of Dermatology & Venereology. Sep2007, Vol. 21 Issue 8, p1019-1026. 8p. 5 Black and White Photographs, 1 Chart.
Subject
*DISEASE management
*DISEASE relapse
*STOMATITIS treatment
*PENTOXIFYLLINE
*ANESTHETICS
*ANTIVIRAL agents
*CENTRAL nervous system depressants
*ALIMENTARY canal inflammation
Language
ISSN
0926-9959
Abstract
Treatment of recurrent aphthous stomatitis (RAS) remains, to date, empirical and non-specific. The main goals of therapy are to minimize pain and functional disabilities as well as decrease inflammatory reactions and frequency of recurrences. Locally, symptomatically acting modalities are the standard treatment in simple cases of RAS. Examples include topical anaesthetics and analgesics, antiseptic and anti-phlogistic preparations, topical steroids as cream, paste or lotions, antacids like sucralfate, chemically stable tetracycline suspension, medicated toothpaste containing the enzymes amyloglucosidase and glucoseoxidase in addition to the well-known silver nitrate application. Dietary management supports the treatment. In more severe cases, topical therapies are again very useful in decreasing the healing time but fail to decrease the interval between attacks. Systemic immunomodulatory agents, like colchicine, pentoxifylline, prednisolone, dapsone, levamisol, thalidomide, azathioprine, methotrexate, cyclosporin A, interferon alpha and tumour necrosis factor (TNF) antagonists, are helpful in resistant cases of major RAS or aphthosis with systemic involvement. [ABSTRACT FROM AUTHOR]