부산대학교 도서관

OBJECTIVE: To report laryngeal movement during simulation for radiation treatment planning in patients with laryngeal carcinoma. METHODS AND MATERIALS: A retrospective review of patients diagnosed with laryngeal carcinoma treated with radiation therapy was done. Movement of the larynx in cephalo-caudal direction was noted with help of fluoroscopic images taken during resting and deglutition phases. Information of variables such as patients age, gender, tracheostomy status, stage of disease and sub-site of disease were recorded. Simple linear regression was used to assess the linear relationship between laryngeal movement and different variables. RESULTS: A total of 47 patients were identified between February 2006 and December 2017 whose laryngeal movement was documented during simulation. About half of the patients had stage I disease (n = 22 [46.8%]). In majority of the patients, the disease originated in glottis (n = 37 [78.7%]). The mean laryngeal movement was noted to be 0.96 cm (SD of 0.392, range: 0.5-2.0cm). There was no linear association observed between laryngeal movement and age (p = 0.239), gender (p = 0.369), tracheostomy status (p = 0.664), stage of disease (p = 0.322) or sub-site of disease (p = 0.761). CONCLUSION: In this era of precision, recording laryngeal movement and incorporating in contouring remains important because it can lead to geometrical miss of target volume during radiation delivery. Our study shows a physiological motion of nearly 1 cm in a cephalo-caudal direction. We conclude that a cautious margin of planning target volume (PTV) should be considered and incorporated during radiation planning of laryngeal cancers. [ABSTRACT FROM AUTHOR]