부산대학교 도서관

The International Journal of Molecular Sciences has published a special issue on the sigma-1 and sigma-2 receptors and their potential therapeutic roles. The issue includes fifteen articles that cover various aspects of these receptors, including their chemistry, pharmacology, and therapeutic indications. The articles provide new insights into the signaling functions of sigma-1 receptors, the entry pathway of ligands to the sigma-1 receptor binding site, and the endogenous ligands that control sigma-1 activity. They also explore the pharmacological effects of sigma-1 agonists and antagonists, the development of sigma-1 ligands for the treatment of multiple sclerosis and chronic pain, and the neuroprotective effects of sigma-1 agonists in neurodegenerative diseases. Additionally, the issue discusses the sigma-2 receptor and its involvement in age-related diseases and cancer, as well as the development of sigma-2 ligands as potential antiproliferative agents. The articles highlight the potential of targeting sigma-1 and sigma-2 receptors for the development of novel therapeutic strategies. The article titled "Conflicts of Interest" by Carmen Abate and Tangui Maurice briefly addresses the issue of conflicts of interest in research, with the authors declaring that they have no conflicts of interest. [Extracted from the article]