부산대학교 도서관

This article discusses the importance of accurately determining a female patient's RhD type during pregnancy to assess the risk of alloimmunization and subsequent hemolytic disease of the fetus and newborn (HDFN). While most patients with weak RhD can be managed as RhD positive, there is a small minority of patients with other variant RHD alleles who are at risk of alloimmunization and may be missed under current management practices. The article presents a case study of two siblings of African descent who demonstrated challenges in managing individuals with serologically weak or negative RhD types. The limitations of serological testing, particularly in identifying variants in non-Northern European populations, are highlighted. The article concludes that early RHD genotyping should be used to resolve serologic weak RhD phenotypes in pregnancy to reduce alloimmunization and prevent unnecessary costs and risks associated with RhIG administration. [Extracted from the article]