학술논문
The Effect of Trapidil and Bevacizumab on Tracheal Anastomotic Wound Healing.
Document Type
Article
Author
Source
Subject
*VASODILATORS
*ANIMAL experimentation
*INFLAMMATION
*RATS
*TRACHEAL diseases
*WOUND healing
*SURGICAL anastomosis
*THERAPEUTICS
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Language
ISSN
0011-393X
Abstract
Background: Although bevacizumab has deleterious effects on the healing of colonic anastomoses, trapidil improves wound healing of colonic and tracheal anastomoses. Objective: We aimed to assess the effects of bevacizumab and trapidil on wound healing after tracheal transection. Materials and methods: We evaluated 35 rats divided in 5 groups: bevacizumab (Group I, n = 7), trapidil (Group II, n = 7), trapidil + bevacizumab (Group III, n = 7), controls (Group IV, n = 7), and sham (Group V, n = 7). Anastomotic healing was assessed by measurement of bursting pressure and inflammation score at the anastomotic region on the seventh day. Results: The bursting pressures of Group II, Group III, and Group V were significantly higher than controls (P = 0.001, P = 0.033, and P = 0.035, respectively). Fibrosis was significantly high in the sham group when compared with the other four groups (P = 0.047). Conclusions: Although bevacizumab seems to impair anastomotic healing, trapidil can be suggested to improve tracheal anastomoses. [Copyright &y& Elsevier]