부산대학교 도서관

국외단행본

Essential discrete mathematics for computer science / by Harry Lewis and Rachel Zax.

xii, 388 p. : ill. ; 27 cm.

Includes bibliographical references and index.

Section one : Basic sciences: the caduceus of cancer-immune responsiveness and cancer biology ; Genomic determinants of cancer immune response and resistance ; Human tumor antigens recognized by T lymphocytes ; Structural and functional defects in HLA class I antigen processing machinery in cancer cells: molecular mechanisms and clinical relevance ; Systems biology T cells ; Activation of CD4⁺T lymphocytes ; Regulation of cell-mediated immunity: the biology of checkpoints and regulator T cells -- B cells in solid tumors: their role in tumor pathogenesis and antitumor immunity ; Functional status of T cells: stemness versus terminal differentation ; The innate immune system: macrophages and neurtrophils -- Natural killer cell effector mechanisms against solid tumors and leukemias and their exploitation in immunotherapy ; Immunogenic cell death and cancer ; Cancer cell-intrinsic pathways of immune resistance ; Chemokines and chemokine receptors: regulators of tumor immunity ; Role of the tumor microenvironment ; Cancer-immune exclusion: an enigmatic phenomenon ; Cancer biomarkers: tumor-infiltrating T cells, programmed death-ligand 1, and tumor mutation burden -- Role of the microbiota in carcinogenesis and cancer therapy ; Synthetic biology for the immunotherapy of cancer -- Section two : Cancer immunotherapy targets and classes. Introduction to principles of cancer immunotherapy ; Manipulating innate immune pathways for cancer immunotherapy ; Cancer vaccines: considerations of antigen, formulation, and delivery ; T cell modulatory cytokines ; Non-engineered adoptive T cell therapy ; CAR T cell therapy ; Immunotherapy based on blocking T cell inhibitory pathways ; Agnostic antibodies to co-stimulatory molecules ; Immune effects of conventional cancer therapeutics ; Oncolytic viruses ; Metabolism of tumor immunity ; Principles of combination immunotherapies -- Section three : Immune function in cancer patients. Introduction to immune function in cancer patients ; Tumor-infiltrating myeloid cells in cancer progression and therapy response ; Intratumoral gene signatures and host genetic variations associated with immune responsiveness ; Impact of somatic mutations on the local and systemic antitumor immune response ; Tumor antigen profiling ; Assessment of antitumor immunity in blood and lymph nodes ; Regulatory T cell biology and its applications in cancer immunotherapy ; Systemic measure of immune function in cancer patients: other suppressive cellular mechanisms ; Circulating mediators of tumor-induced immune suppression ; Harnessing B cells and tertiary lymphoid structures for antitumor immunity ; Blood transcriptomic approaches to cancer immunotherapy ; Advances in techniques for immunotherapy biomarker analysis ; Predicitve biomarkers (programmed death ligand 1 expression, microsatellite instability, and tumor mutational burden) for response to immune checkpoint inhibitors ; Tumor microenvironment metabolism as a primordial checkpoint in antitumor T cell immunity ; Age-related immune function changes as they relate to cancer immunotherapy ; Clinical measures: tumor response assessments, pseudoprogression, and immunometabolism -- Section four : Disease-specific treatments and outcomes. Introduction: general approach to cancer immunotherapy-lessons learned from the past years ; Immunotherapy in melanoma ; Other cutaneous tumors: basal cell carcinoma, cutaneous squamous cell carcinoma, Merkel cell carcinoma, and cutaneous sarcomas ; Immunotherapy in genitourinary ; Immunotherapy in gastrointestinal ; Immunotherapy of hepatocellular carcinoma ; Immunotherapy for gynecologic malignancies ; Breast cancer immunotherapy ; Immunotherapy for lung cancer and malignant pleural mesothelioma ; Heak and neck cancer ; Immunotherapy for hematologic malignancies: lymphomas, leukemias, and myeloma ; Brain tumors ; Sarcomas ; Pediatric cancers: neuroblastoma ; Immunotherapy in combination with radiation therapy -- Section five : Regulatory aspects of the biological therapy of cancer. Regulatory considerations for therapeutic cancer vaccines ; A regulatory perspective on cell therapy for cancer: chemistry, manufacturing and control, preclinical, and clinical ; Combination immunotherapies: regulatory considerations ; Regulatory considerations for in vitro companion diagnostic devices.

Discrete mathematics is the basis of much of computer science, from algorithms and automata theory to combinatorics and graph theory. Essential Discrete Mathematics for Computer Science aims to teach mathematical reasoning as well as concepts and skills by stressing the art of proof. It is fully illustrated in color, and each chapter includes a concise summary as well as a set of exercises.--Source other than the Library of Congress.

Cancer, Immunotherapy.
Tumors, Immunological aspects.
Computer science, Mathematics.

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