소장자료
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100 | 1 | ▼aKlug, William S.▲ | |
245 | 1 | 0 | ▼aEssentials of Genetics, Global Edition.▲ |
250 | ▼a9th ed.▲ | ||
264 | 1 | ▼aHarlow :▼bPearson Education Limited,▼c2016.▲ | |
264 | 4 | ▼c짤2016.▲ | |
300 | ▼a1 online resource (606 pages)▲ | ||
336 | ▼atext▼btxt▼2rdacontent▲ | ||
337 | ▼acomputer▼bc▼2rdamedia▲ | ||
338 | ▼aonline resource▼bcr▼2rdacarrier▲ | ||
505 | 0 | ▼aCover -- Title Page -- Copyright Page -- About the Authors -- Preface -- Acknowledgments -- Contents -- 1 Introduction to Genetics -- 1.1 Genetics Has a Rich and Interesting History -- 1.2 Genetics Progressed from Mendel to DNA in Less Than a Century -- 1.3 Discovery of the Double Helix Launched the Era of Molecular Genetics -- 1.4 Development of Recombinant DNA Technology Began the Era of DNA Cloning -- 1.5 The Impact of Biotechnology Is Continually Expanding -- 1.6 Genomics, Proteomics, and Bioinformatics Are New and Expanding Fields -- 1.7 Genetic Studies Rely on the Use of Model Organisms -- 1.8 We Live in the Age of Genetics -- Problems and Discussion Questions -- 2 Mitosis and Meiosis -- 2.1 Cell Structure Is Closely Tied to Genetic Function -- 2.2 Chromosomes Exist in Homologous Pairs in Diploid Organisms -- 2.3 Mitosis Partitions Chromosomes into Dividing Cells -- 2.4 Meiosis Creates Haploid Gametes and Spores and Enhances Genetic Variation in Species -- 2.5 The Development of Gametes Varies in Spermatogenesis Compared to Oogenesis -- 2.6 Meiosis Is Critical to Sexual Reproduction in All Diploid Organisms -- 2.7 Electron Microscopy Has Revealed the Physical Structure of Mitotic and Meiotic Chromosomes -- EXPLORING GENOMICS: PubMed: Exploring and Retrieving Biomedical Literature -- CASE STUDY:Triggering meiotic maturation of oocytes -- Insights and Solutions -- Problems and Discussion Questions -- 3 Mendelian Genetics -- 3.1 Mendel Used a Model Experimental Approach to Study Patterns of Inheritance -- 3.2 The Monohybrid Cross Reveals How One Trait Is Transmitted from Generation to Generation -- 3.3 Mendel's Dihybrid Cross Generated a Unique F[Sub(2)] Ratio -- 3.4 The Trihybrid Cross Demonstrates That Mendel's Principles Apply to Inheritance of Multiple Traits -- 3.5 Mendel's Work Was Rediscovered in the Early Twentieth Century.▲ | |
505 | 8 | ▼aEvolving Concept of the Gene -- 3.6 Independent Assortment Leads to Extensive Genetic Variation -- 3.7 Laws of Probability Help to Explain Genetic Events -- 3.8 Chi-Square Analysis Evaluates the Influence of Chance on Genetic Data -- 3.9 Pedigrees Reveal Patterns of Inheritance of Human Traits -- 3.10 Tay-Sachs Disease: The Molecular Basis of a Recessive Disorder in Humans -- EXPLORING GENOMICS: Online Mendelian Inheritance in Man -- CASE STUDY:To test or not to test -- Insights and Solutions -- Problems and Discussion Questions -- 4 Modification of Mendelian Ratios -- 4.1 Alleles Alter Phenotypes in Different Ways -- 4.2 Geneticists Use a Variety of Symbols for Alleles -- 4.3 Neither Allele Is Dominant in Incomplete, or Partial, Dominance -- 4.4 In Codominance, the Influence of Both Alleles in a Heterozygote Is Clearly Evident -- 4.5 Multiple Alleles of a Gene May Exist in a Population -- 4.6 Lethal Alleles Represent Essential Genes -- Evolving Concept of the Gene -- 4.7 Combinations of Two Gene Pairs with Two Modes of Inheritance Modify the 9:3:3:1 Ratio -- 4.8 Phenotypes Are Often Affected by More Than One Gene -- 4.9 Complementation Analysis Can Determine If Two Mutations Causing a Similar Phenotype Are Alleles of the Same Gene -- 4.10 Expression of a Single Gene May Have Multiple Effects -- 4.11 X-Linkage Describes Genes on the X Chromosome -- 4.12 In Sex-Limited and Sex-Influenced Inheritance, an Individual's Sex Influences the Phenotype -- 4.13 Genetic Background and the Environment Affect Phenotypic Expression -- 4.14 Genomic (Parental) Imprinting and Gene Silencing -- 4.15 Extranuclear Inheritance Modifies Mendelian Patterns -- GENETICS, TECHNOLOGY, AND SOCIETY: Improving the Genetic Fate of Purebred Dogs -- CASE STUDY: Sudden blindness -- Insights and Solutions -- Problems and Discussion Questions -- 5 Sex Determination and Sex Chromosomes.▲ | |
505 | 8 | ▼a5.1 X and Y Chromosomes Were First Linked to Sex Determination Early in the Twentieth Century -- 5.2 The Y Chromosome Determines Maleness in Humans -- 5.3 The Ratio of Males to Females in Humans Is Not 1.0 -- 5.4 Dosage Compensation Prevents Excessive Expression of X-Linked Genes in Humans and Other Mammals -- 5.5 The Ratio of X Chromosomes to Sets of Autosomes Can Determine Sex -- 5.6 Temperature Variation Controls Sex Determination in Reptiles -- CASE STUDY: Not reaching puberty -- Insights and Solutions -- Problems and Discussion Questions -- 6 Chromosome Mutations: Variation in Number and Arrangement -- 6.1 Variation in Chromosome Number: Terminology and Origin -- 6.2 Monosomy and Trisomy Result in a Variety of Phenotypic Effects -- 6.3 Polyploidy, in Which More Than Two Haploid Sets of Chromosomes Are Present, Is Prevalent in Plants -- 6.4 Variation Occurs in the Composition and Arrangement of Chromosomes -- 6.5 A Deletion Is a Missing Region of a Chromosome -- 6.6 A Duplication Is a Repeated Segment of a Chromosome -- 6.7 Inversions Rearrange the Linear Gene Sequence -- 6.8 Translocations Alter the Location of Chromosomal Segments in the Genome -- 6.9 Fragile Sites in Human Chromosomes Are Susceptible to Breakage -- CASE STUDY: Changing the face of Down syndrome -- Insights and Solutions -- Problems and Discussion Questions -- 7 Linkage and Chromosome Mapping in Eukaryotes -- 7.1 Genes Linked on the Same Chromosome Segregate Together -- 7.2 Crossing Over Serves as the Basis of Determining the Distance between Genes during Mapping -- 7.3 Determining the Gene Sequence during Mapping Requires the Analysis of Multiple Crossovers -- 7.4 As the Distance between Two Genes Increases, Mapping Estimates Become More Inaccurate -- Evolving Concept of the Gene -- 7.5 Chromosome Mapping Is Now Possible Using DNA Markers and Annotated Computer Databases.▲ | |
505 | 8 | ▼a7.6 Other Aspects of Genetic Exchange -- EXPLORING GENOMICS: Human Chromosome Maps on the Internet -- CASE STUDY: Links to autism -- Insights and Solutions -- Problems and Discussion Questions -- 8 Genetic Analysis and Mapping in Bacteria and Bacteriophages -- 8.1 Bacteria Mutate Spontaneously and Are Easily Cultured -- 8.2 Genetic Recombination Occurs in Bacteria -- 8.3 Rec Proteins Are Essential to Bacterial Recombination -- 8.4 The F Factor Is an Example of a Plasmid -- 8.5 Transformation Is Another Process Leading to Genetic Recombination in Bacteria -- 8.6 Bacteriophages Are Bacterial Viruses -- 8.7 Transduction Is Virus-Mediated Bacterial DNA Transfer -- CASE STUDY: To treat or not to treat -- Insights and Solutions -- Problems and Discussion Questions -- 9 DNA Structure and Analysis -- 9.1 The Genetic Material Must Exhibit Four Characteristics -- 9.2 Until 1944, Observations Favored Protein as the Genetic Material -- 9.3 Evidence Favoring DNA as the Genetic Material Was First Obtained during the Study of Bacteria and Bacteriophages -- 9.4 Indirect and Direct Evidence Supports the Concept that DNA Is the Genetic Material in Eukaryotes -- 9.5 RNA Serves as the Genetic Material in Some Viruses -- 9.6 The Structure of DNA Holds the Key to Understanding Its Function -- Evolving Concept of the Gene -- 9.7 Alternative Forms of DNA Exist -- 9.8 The Structure of RNA Is Chemically Similar to DNA, but Single-Stranded -- 9.9 Many Analytical Techniques Have Been Useful during the Investigation of DNA and RNA -- EXPLORING GENOMICS: Introduction to Bioinformatics: BLAST -- CASE STUDY: Zigs and zags of the smallpox virus -- Insights and Solutions -- Problems and Discussion Questions -- 10 DNA Replication and Recombination -- 10.1 DNA Is Reproduced by Semiconservative Replication.▲ | |
505 | 8 | ▼a10.2 DNA Synthesis in Bacteria Involves Five Polymerases, as Well as Other Enzymes -- 10.3 Many Complex Issues Must Be Resolved during DNA Replication -- 10.4 A Coherent Model Summarizes DNA Replication -- 10.5 Replication Is Controlled by a Variety of Genes -- 10.6 Eukaryotic DNA Replication Is Similar to Replication in Prokaryotes, but Is More Complex -- 10.7 The Ends of Linear Chromosomes Are Problematic during Replication -- GENETICS, TECHNOLOGY, AND SOCIETY: Telomeres: The Key to Immortality? -- CASE STUDY: Premature aging and DNA helicases -- Insights and Solutions -- Problems and Discussion Questions -- 11 Chromosome Structure and DNA Sequence Organization -- 11.1 Viral and Bacterial Chromosomes Are Relatively Simple DNA Molecules -- 11.2 Mitochondria and Chloroplasts Contain DNA Similar to Bacteria and Viruses -- 11.3 Specialized Chromosomes Reveal Variations in the Organization of DNA -- 11.4 DNA Is Organized into Chromatin in Eukaryotes -- 11.5 Eukaryotic Genomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA -- 11.6 The Vast Majority of a Eukaryotic Genome Does Not Encode Functional Genes -- EXPLORING GENOMICS: Database of Genomic Variants: Structural Variations in the Human Genome -- CASE STUDY: Art inspires learning -- Insights and Solutions -- Problems and Discussion Questions -- 12 The Genetic Code and Transcription -- 12.1 The Genetic Code Exhibits a Number of Characteristics -- 12.2 Early Studies Established the Basic Operational Patterns of the Code -- 12.3 Studies by Nirenberg, Matthaei, and Others Deciphered the Code -- 12.4 The Coding Dictionary Reveals the Function of the 64 Triplets -- 12.5 The Genetic Code Has Been Confirmed in Studies of Bacteriophage MS2 -- 12.6 The Genetic Code Is Nearly Universal -- 12.7 Different Initiation Points Create Overlapping Genes.▲ | |
505 | 8 | ▼a12.8 Transcription Synthesizes RNA on a DNA Template.▲ | |
520 | ▼aFor all introductory genetics courses � A forward-looking exploration of essential genetics topics Known for its focus on conceptual understanding, problem solving, and practical applications, this bestseller strengthens problem-solving skills and explores the essential genetics topics that today's students need to understand. The Ninth Edition maintains the text's brief, less-detailed coverage of core concepts and has been extensively updated with relevant, cutting-edge coverage of emerging topics in genetics. � � MasteringGenetics�� is not included. Students, if MasteringGenetics is a recommended/mandatory component of the course, please ask your instructor for the correct ISBN. MasteringGenetics should only be purchased when required by an instructor. Instructors, contact your Pearson representative for more information. Also Available with MasteringGenetics�� This title is also available with MasteringGenetics - an online homework and assessment program that guides students through complex topics in genetics and strengthens problem-solving skills using in-depth tutorials that coach students to the correct answers with hints and feedback specific to their misconceptions and errors. MasteringGenetics offers additional opportunities for students to master key concepts and practice problem solving, using interactive tutorials with hints and feedback. Instructors may also assign pre-lecture quizzes, end-of-chapter problems, practice problems, and test bank questions that are automatically scored and entered into the Mastering gradebook. � Students, if interested in purchasing this title with MasteringGenetics, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information.▲ | ||
588 | ▼aDescription based on publisher supplied metadata and other sources.▲ | ||
590 | ▼aElectronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2019. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries. ▲ | ||
650 | 0 | ▼aGenetics.▲ | |
650 | 0 | ▼aGenetics-Textbooks.▲ | |
655 | 4 | ▼aElectronic books.▲ | |
700 | 1 | ▼aCummings, Michael R.▲ | |
700 | 1 | ▼aSpencer, Charlotte A.▲ | |
700 | 1 | ▼aPalladino, Michael A.▲ | |
776 | 0 | 8 | ▼iPrint version:▼aKlug, William S.▼tEssentials of Genetics, Global Edition▼dHarlow : Pearson Education Limited,c2016▼z9781292108865▲ |
797 | 2 | ▼aProQuest (Firm)▲ | |
856 | 4 | 0 | ▼uhttps://ebookcentral.proquest.com/lib/pusan/detail.action?docID=5185715▼zClick to View▲ |
Essentials of Genetics, Global Edition
자료유형
국외eBook
서명/책임사항
Essentials of Genetics, Global Edition.
판사항
9th ed.
형태사항
1 online resource (606 pages)
내용주기
Cover -- Title Page -- Copyright Page -- About the Authors -- Preface -- Acknowledgments -- Contents -- 1 Introduction to Genetics -- 1.1 Genetics Has a Rich and Interesting History -- 1.2 Genetics Progressed from Mendel to DNA in Less Than a Century -- 1.3 Discovery of the Double Helix Launched the Era of Molecular Genetics -- 1.4 Development of Recombinant DNA Technology Began the Era of DNA Cloning -- 1.5 The Impact of Biotechnology Is Continually Expanding -- 1.6 Genomics, Proteomics, and Bioinformatics Are New and Expanding Fields -- 1.7 Genetic Studies Rely on the Use of Model Organisms -- 1.8 We Live in the Age of Genetics -- Problems and Discussion Questions -- 2 Mitosis and Meiosis -- 2.1 Cell Structure Is Closely Tied to Genetic Function -- 2.2 Chromosomes Exist in Homologous Pairs in Diploid Organisms -- 2.3 Mitosis Partitions Chromosomes into Dividing Cells -- 2.4 Meiosis Creates Haploid Gametes and Spores and Enhances Genetic Variation in Species -- 2.5 The Development of Gametes Varies in Spermatogenesis Compared to Oogenesis -- 2.6 Meiosis Is Critical to Sexual Reproduction in All Diploid Organisms -- 2.7 Electron Microscopy Has Revealed the Physical Structure of Mitotic and Meiotic Chromosomes -- EXPLORING GENOMICS: PubMed: Exploring and Retrieving Biomedical Literature -- CASE STUDY:Triggering meiotic maturation of oocytes -- Insights and Solutions -- Problems and Discussion Questions -- 3 Mendelian Genetics -- 3.1 Mendel Used a Model Experimental Approach to Study Patterns of Inheritance -- 3.2 The Monohybrid Cross Reveals How One Trait Is Transmitted from Generation to Generation -- 3.3 Mendel's Dihybrid Cross Generated a Unique F[Sub(2)] Ratio -- 3.4 The Trihybrid Cross Demonstrates That Mendel's Principles Apply to Inheritance of Multiple Traits -- 3.5 Mendel's Work Was Rediscovered in the Early Twentieth Century.
Evolving Concept of the Gene -- 3.6 Independent Assortment Leads to Extensive Genetic Variation -- 3.7 Laws of Probability Help to Explain Genetic Events -- 3.8 Chi-Square Analysis Evaluates the Influence of Chance on Genetic Data -- 3.9 Pedigrees Reveal Patterns of Inheritance of Human Traits -- 3.10 Tay-Sachs Disease: The Molecular Basis of a Recessive Disorder in Humans -- EXPLORING GENOMICS: Online Mendelian Inheritance in Man -- CASE STUDY:To test or not to test -- Insights and Solutions -- Problems and Discussion Questions -- 4 Modification of Mendelian Ratios -- 4.1 Alleles Alter Phenotypes in Different Ways -- 4.2 Geneticists Use a Variety of Symbols for Alleles -- 4.3 Neither Allele Is Dominant in Incomplete, or Partial, Dominance -- 4.4 In Codominance, the Influence of Both Alleles in a Heterozygote Is Clearly Evident -- 4.5 Multiple Alleles of a Gene May Exist in a Population -- 4.6 Lethal Alleles Represent Essential Genes -- Evolving Concept of the Gene -- 4.7 Combinations of Two Gene Pairs with Two Modes of Inheritance Modify the 9:3:3:1 Ratio -- 4.8 Phenotypes Are Often Affected by More Than One Gene -- 4.9 Complementation Analysis Can Determine If Two Mutations Causing a Similar Phenotype Are Alleles of the Same Gene -- 4.10 Expression of a Single Gene May Have Multiple Effects -- 4.11 X-Linkage Describes Genes on the X Chromosome -- 4.12 In Sex-Limited and Sex-Influenced Inheritance, an Individual's Sex Influences the Phenotype -- 4.13 Genetic Background and the Environment Affect Phenotypic Expression -- 4.14 Genomic (Parental) Imprinting and Gene Silencing -- 4.15 Extranuclear Inheritance Modifies Mendelian Patterns -- GENETICS, TECHNOLOGY, AND SOCIETY: Improving the Genetic Fate of Purebred Dogs -- CASE STUDY: Sudden blindness -- Insights and Solutions -- Problems and Discussion Questions -- 5 Sex Determination and Sex Chromosomes.
5.1 X and Y Chromosomes Were First Linked to Sex Determination Early in the Twentieth Century -- 5.2 The Y Chromosome Determines Maleness in Humans -- 5.3 The Ratio of Males to Females in Humans Is Not 1.0 -- 5.4 Dosage Compensation Prevents Excessive Expression of X-Linked Genes in Humans and Other Mammals -- 5.5 The Ratio of X Chromosomes to Sets of Autosomes Can Determine Sex -- 5.6 Temperature Variation Controls Sex Determination in Reptiles -- CASE STUDY: Not reaching puberty -- Insights and Solutions -- Problems and Discussion Questions -- 6 Chromosome Mutations: Variation in Number and Arrangement -- 6.1 Variation in Chromosome Number: Terminology and Origin -- 6.2 Monosomy and Trisomy Result in a Variety of Phenotypic Effects -- 6.3 Polyploidy, in Which More Than Two Haploid Sets of Chromosomes Are Present, Is Prevalent in Plants -- 6.4 Variation Occurs in the Composition and Arrangement of Chromosomes -- 6.5 A Deletion Is a Missing Region of a Chromosome -- 6.6 A Duplication Is a Repeated Segment of a Chromosome -- 6.7 Inversions Rearrange the Linear Gene Sequence -- 6.8 Translocations Alter the Location of Chromosomal Segments in the Genome -- 6.9 Fragile Sites in Human Chromosomes Are Susceptible to Breakage -- CASE STUDY: Changing the face of Down syndrome -- Insights and Solutions -- Problems and Discussion Questions -- 7 Linkage and Chromosome Mapping in Eukaryotes -- 7.1 Genes Linked on the Same Chromosome Segregate Together -- 7.2 Crossing Over Serves as the Basis of Determining the Distance between Genes during Mapping -- 7.3 Determining the Gene Sequence during Mapping Requires the Analysis of Multiple Crossovers -- 7.4 As the Distance between Two Genes Increases, Mapping Estimates Become More Inaccurate -- Evolving Concept of the Gene -- 7.5 Chromosome Mapping Is Now Possible Using DNA Markers and Annotated Computer Databases.
7.6 Other Aspects of Genetic Exchange -- EXPLORING GENOMICS: Human Chromosome Maps on the Internet -- CASE STUDY: Links to autism -- Insights and Solutions -- Problems and Discussion Questions -- 8 Genetic Analysis and Mapping in Bacteria and Bacteriophages -- 8.1 Bacteria Mutate Spontaneously and Are Easily Cultured -- 8.2 Genetic Recombination Occurs in Bacteria -- 8.3 Rec Proteins Are Essential to Bacterial Recombination -- 8.4 The F Factor Is an Example of a Plasmid -- 8.5 Transformation Is Another Process Leading to Genetic Recombination in Bacteria -- 8.6 Bacteriophages Are Bacterial Viruses -- 8.7 Transduction Is Virus-Mediated Bacterial DNA Transfer -- CASE STUDY: To treat or not to treat -- Insights and Solutions -- Problems and Discussion Questions -- 9 DNA Structure and Analysis -- 9.1 The Genetic Material Must Exhibit Four Characteristics -- 9.2 Until 1944, Observations Favored Protein as the Genetic Material -- 9.3 Evidence Favoring DNA as the Genetic Material Was First Obtained during the Study of Bacteria and Bacteriophages -- 9.4 Indirect and Direct Evidence Supports the Concept that DNA Is the Genetic Material in Eukaryotes -- 9.5 RNA Serves as the Genetic Material in Some Viruses -- 9.6 The Structure of DNA Holds the Key to Understanding Its Function -- Evolving Concept of the Gene -- 9.7 Alternative Forms of DNA Exist -- 9.8 The Structure of RNA Is Chemically Similar to DNA, but Single-Stranded -- 9.9 Many Analytical Techniques Have Been Useful during the Investigation of DNA and RNA -- EXPLORING GENOMICS: Introduction to Bioinformatics: BLAST -- CASE STUDY: Zigs and zags of the smallpox virus -- Insights and Solutions -- Problems and Discussion Questions -- 10 DNA Replication and Recombination -- 10.1 DNA Is Reproduced by Semiconservative Replication.
10.2 DNA Synthesis in Bacteria Involves Five Polymerases, as Well as Other Enzymes -- 10.3 Many Complex Issues Must Be Resolved during DNA Replication -- 10.4 A Coherent Model Summarizes DNA Replication -- 10.5 Replication Is Controlled by a Variety of Genes -- 10.6 Eukaryotic DNA Replication Is Similar to Replication in Prokaryotes, but Is More Complex -- 10.7 The Ends of Linear Chromosomes Are Problematic during Replication -- GENETICS, TECHNOLOGY, AND SOCIETY: Telomeres: The Key to Immortality? -- CASE STUDY: Premature aging and DNA helicases -- Insights and Solutions -- Problems and Discussion Questions -- 11 Chromosome Structure and DNA Sequence Organization -- 11.1 Viral and Bacterial Chromosomes Are Relatively Simple DNA Molecules -- 11.2 Mitochondria and Chloroplasts Contain DNA Similar to Bacteria and Viruses -- 11.3 Specialized Chromosomes Reveal Variations in the Organization of DNA -- 11.4 DNA Is Organized into Chromatin in Eukaryotes -- 11.5 Eukaryotic Genomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA -- 11.6 The Vast Majority of a Eukaryotic Genome Does Not Encode Functional Genes -- EXPLORING GENOMICS: Database of Genomic Variants: Structural Variations in the Human Genome -- CASE STUDY: Art inspires learning -- Insights and Solutions -- Problems and Discussion Questions -- 12 The Genetic Code and Transcription -- 12.1 The Genetic Code Exhibits a Number of Characteristics -- 12.2 Early Studies Established the Basic Operational Patterns of the Code -- 12.3 Studies by Nirenberg, Matthaei, and Others Deciphered the Code -- 12.4 The Coding Dictionary Reveals the Function of the 64 Triplets -- 12.5 The Genetic Code Has Been Confirmed in Studies of Bacteriophage MS2 -- 12.6 The Genetic Code Is Nearly Universal -- 12.7 Different Initiation Points Create Overlapping Genes.
12.8 Transcription Synthesizes RNA on a DNA Template.
Evolving Concept of the Gene -- 3.6 Independent Assortment Leads to Extensive Genetic Variation -- 3.7 Laws of Probability Help to Explain Genetic Events -- 3.8 Chi-Square Analysis Evaluates the Influence of Chance on Genetic Data -- 3.9 Pedigrees Reveal Patterns of Inheritance of Human Traits -- 3.10 Tay-Sachs Disease: The Molecular Basis of a Recessive Disorder in Humans -- EXPLORING GENOMICS: Online Mendelian Inheritance in Man -- CASE STUDY:To test or not to test -- Insights and Solutions -- Problems and Discussion Questions -- 4 Modification of Mendelian Ratios -- 4.1 Alleles Alter Phenotypes in Different Ways -- 4.2 Geneticists Use a Variety of Symbols for Alleles -- 4.3 Neither Allele Is Dominant in Incomplete, or Partial, Dominance -- 4.4 In Codominance, the Influence of Both Alleles in a Heterozygote Is Clearly Evident -- 4.5 Multiple Alleles of a Gene May Exist in a Population -- 4.6 Lethal Alleles Represent Essential Genes -- Evolving Concept of the Gene -- 4.7 Combinations of Two Gene Pairs with Two Modes of Inheritance Modify the 9:3:3:1 Ratio -- 4.8 Phenotypes Are Often Affected by More Than One Gene -- 4.9 Complementation Analysis Can Determine If Two Mutations Causing a Similar Phenotype Are Alleles of the Same Gene -- 4.10 Expression of a Single Gene May Have Multiple Effects -- 4.11 X-Linkage Describes Genes on the X Chromosome -- 4.12 In Sex-Limited and Sex-Influenced Inheritance, an Individual's Sex Influences the Phenotype -- 4.13 Genetic Background and the Environment Affect Phenotypic Expression -- 4.14 Genomic (Parental) Imprinting and Gene Silencing -- 4.15 Extranuclear Inheritance Modifies Mendelian Patterns -- GENETICS, TECHNOLOGY, AND SOCIETY: Improving the Genetic Fate of Purebred Dogs -- CASE STUDY: Sudden blindness -- Insights and Solutions -- Problems and Discussion Questions -- 5 Sex Determination and Sex Chromosomes.
5.1 X and Y Chromosomes Were First Linked to Sex Determination Early in the Twentieth Century -- 5.2 The Y Chromosome Determines Maleness in Humans -- 5.3 The Ratio of Males to Females in Humans Is Not 1.0 -- 5.4 Dosage Compensation Prevents Excessive Expression of X-Linked Genes in Humans and Other Mammals -- 5.5 The Ratio of X Chromosomes to Sets of Autosomes Can Determine Sex -- 5.6 Temperature Variation Controls Sex Determination in Reptiles -- CASE STUDY: Not reaching puberty -- Insights and Solutions -- Problems and Discussion Questions -- 6 Chromosome Mutations: Variation in Number and Arrangement -- 6.1 Variation in Chromosome Number: Terminology and Origin -- 6.2 Monosomy and Trisomy Result in a Variety of Phenotypic Effects -- 6.3 Polyploidy, in Which More Than Two Haploid Sets of Chromosomes Are Present, Is Prevalent in Plants -- 6.4 Variation Occurs in the Composition and Arrangement of Chromosomes -- 6.5 A Deletion Is a Missing Region of a Chromosome -- 6.6 A Duplication Is a Repeated Segment of a Chromosome -- 6.7 Inversions Rearrange the Linear Gene Sequence -- 6.8 Translocations Alter the Location of Chromosomal Segments in the Genome -- 6.9 Fragile Sites in Human Chromosomes Are Susceptible to Breakage -- CASE STUDY: Changing the face of Down syndrome -- Insights and Solutions -- Problems and Discussion Questions -- 7 Linkage and Chromosome Mapping in Eukaryotes -- 7.1 Genes Linked on the Same Chromosome Segregate Together -- 7.2 Crossing Over Serves as the Basis of Determining the Distance between Genes during Mapping -- 7.3 Determining the Gene Sequence during Mapping Requires the Analysis of Multiple Crossovers -- 7.4 As the Distance between Two Genes Increases, Mapping Estimates Become More Inaccurate -- Evolving Concept of the Gene -- 7.5 Chromosome Mapping Is Now Possible Using DNA Markers and Annotated Computer Databases.
7.6 Other Aspects of Genetic Exchange -- EXPLORING GENOMICS: Human Chromosome Maps on the Internet -- CASE STUDY: Links to autism -- Insights and Solutions -- Problems and Discussion Questions -- 8 Genetic Analysis and Mapping in Bacteria and Bacteriophages -- 8.1 Bacteria Mutate Spontaneously and Are Easily Cultured -- 8.2 Genetic Recombination Occurs in Bacteria -- 8.3 Rec Proteins Are Essential to Bacterial Recombination -- 8.4 The F Factor Is an Example of a Plasmid -- 8.5 Transformation Is Another Process Leading to Genetic Recombination in Bacteria -- 8.6 Bacteriophages Are Bacterial Viruses -- 8.7 Transduction Is Virus-Mediated Bacterial DNA Transfer -- CASE STUDY: To treat or not to treat -- Insights and Solutions -- Problems and Discussion Questions -- 9 DNA Structure and Analysis -- 9.1 The Genetic Material Must Exhibit Four Characteristics -- 9.2 Until 1944, Observations Favored Protein as the Genetic Material -- 9.3 Evidence Favoring DNA as the Genetic Material Was First Obtained during the Study of Bacteria and Bacteriophages -- 9.4 Indirect and Direct Evidence Supports the Concept that DNA Is the Genetic Material in Eukaryotes -- 9.5 RNA Serves as the Genetic Material in Some Viruses -- 9.6 The Structure of DNA Holds the Key to Understanding Its Function -- Evolving Concept of the Gene -- 9.7 Alternative Forms of DNA Exist -- 9.8 The Structure of RNA Is Chemically Similar to DNA, but Single-Stranded -- 9.9 Many Analytical Techniques Have Been Useful during the Investigation of DNA and RNA -- EXPLORING GENOMICS: Introduction to Bioinformatics: BLAST -- CASE STUDY: Zigs and zags of the smallpox virus -- Insights and Solutions -- Problems and Discussion Questions -- 10 DNA Replication and Recombination -- 10.1 DNA Is Reproduced by Semiconservative Replication.
10.2 DNA Synthesis in Bacteria Involves Five Polymerases, as Well as Other Enzymes -- 10.3 Many Complex Issues Must Be Resolved during DNA Replication -- 10.4 A Coherent Model Summarizes DNA Replication -- 10.5 Replication Is Controlled by a Variety of Genes -- 10.6 Eukaryotic DNA Replication Is Similar to Replication in Prokaryotes, but Is More Complex -- 10.7 The Ends of Linear Chromosomes Are Problematic during Replication -- GENETICS, TECHNOLOGY, AND SOCIETY: Telomeres: The Key to Immortality? -- CASE STUDY: Premature aging and DNA helicases -- Insights and Solutions -- Problems and Discussion Questions -- 11 Chromosome Structure and DNA Sequence Organization -- 11.1 Viral and Bacterial Chromosomes Are Relatively Simple DNA Molecules -- 11.2 Mitochondria and Chloroplasts Contain DNA Similar to Bacteria and Viruses -- 11.3 Specialized Chromosomes Reveal Variations in the Organization of DNA -- 11.4 DNA Is Organized into Chromatin in Eukaryotes -- 11.5 Eukaryotic Genomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA -- 11.6 The Vast Majority of a Eukaryotic Genome Does Not Encode Functional Genes -- EXPLORING GENOMICS: Database of Genomic Variants: Structural Variations in the Human Genome -- CASE STUDY: Art inspires learning -- Insights and Solutions -- Problems and Discussion Questions -- 12 The Genetic Code and Transcription -- 12.1 The Genetic Code Exhibits a Number of Characteristics -- 12.2 Early Studies Established the Basic Operational Patterns of the Code -- 12.3 Studies by Nirenberg, Matthaei, and Others Deciphered the Code -- 12.4 The Coding Dictionary Reveals the Function of the 64 Triplets -- 12.5 The Genetic Code Has Been Confirmed in Studies of Bacteriophage MS2 -- 12.6 The Genetic Code Is Nearly Universal -- 12.7 Different Initiation Points Create Overlapping Genes.
12.8 Transcription Synthesizes RNA on a DNA Template.
요약주기
For all introductory genetics courses � A forward-looking exploration of essential genetics topics Known for its focus on conceptual understanding, problem solving, and practical applications, this bestseller strengthens problem-solving skills and explores the essential genetics topics that today's students need to understand. The Ninth Edition maintains the text's brief, less-detailed coverage of core concepts and has been extensively updated with relevant, cutting-edge coverage of emerging topics in genetics. � � MasteringGenetics�� is not included. Students, if MasteringGenetics is a recommended/mandatory component of the course, please ask your instructor for the correct ISBN. MasteringGenetics should only be purchased when required by an instructor. Instructors, contact your Pearson representative for more information. Also Available with MasteringGenetics�� This title is also available with MasteringGenetics - an online homework and assessment program that guides students through complex topics in genetics and strengthens problem-solving skills using in-depth tutorials that coach students to the correct answers with hints and feedback specific to their misconceptions and errors. MasteringGenetics offers additional opportunities for students to master key concepts and practice problem solving, using interactive tutorials with hints and feedback. Instructors may also assign pre-lecture quizzes, end-of-chapter problems, practice problems, and test bank questions that are automatically scored and entered into the Mastering gradebook. � Students, if interested in purchasing this title with MasteringGenetics, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information.
기타형태저록
ISBN
9781292108933
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