소장자료
LDR | 04946cam 2200613Ma 4500 | ||
001 | 0100524153▲ | ||
003 | OCoLC▲ | ||
005 | 20210909163751▲ | ||
007 | ta ▲ | ||
008 | 121227s1984 gw o 000 0 eng c▲ | ||
020 | ▼z9783642694905 (ebk.)▲ | ||
020 | ▼z364269490X (ebk.)▲ | ||
020 | ▼a9783642694929▲ | ||
020 | ▼a3642694926▲ | ||
035 | ▼a(OCoLC)840294386▼z(OCoLC)968654216▲ | ||
040 | ▼aI9W▼beng▼epn▼cI9W▼dOCLCQ▼dUV0▼dOCLCO▼dGW5XE▼dOCLCF▼dCOO▼dEBLCP▼dOCLCQ▼dYDX▼dUAB▼dOCLCQ▼dAU@▼dLEAUB▼dOCLCQ▼dUKAHL▼d221016▲ | ||
082 | 0 | 4 | ▼a615▼223▲ |
090 | ▼a615▼bF791a▲ | ||
100 | 1 | ▼aFox, Brian W.▲ | |
245 | 1 | 0 | ▼aAntitumor Drug Resistance /▼cedited by Brian W. Fox, Margaret Fox.▲ |
246 | 3 | ▼aWith contributions by numerous experts▲ | |
260 | ▼aBerlin, Heidelberg :▼bSpringer Berlin Heidelberg,▼c1984.▲ | ||
300 | ▼aXXV, 738 p. ;▼c25 cm.▲ | ||
490 | 0 | ▼aHandbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie, 0171-2004 ;▼v72▲ | |
505 | 0 | ▼aSection I: Concepts of Drug Resistance -- 1 Clinical Setting -- 2 Experimental Setting -- Section II: Modification of Host-Tumor Interaction -- 3 Drug Disposition and Pharmacology -- 4 Immunological Changes -- 5 The Molecular Basis of Genetically Acquired Resistance to Purine Analogues in Cultured Mammalian Cells -- Section III: Cellular Aspects -- 6 Cell Cycle Perturbation Effects -- 7 Tumour Resistance and the Phenomenon of Inflammatory-Cell Infiltration -- 8 Flow Cytometric Methods for Studying Enzyme Activity in Populations of Individual Cells -- 9 Chromosome Studies -- 10 Alterations of Drug Transport -- 11 Cell Hybridisation -- Section IV: Modification of Tumor Biochemistry -- 12 Drug Resistance and DNA Repair -- 13 Cyclic AMP and Prostaglandins -- 14 Properties of Mitochondria -- 15 Mechanism of "Resistance" Towards Specific Drug Groups -- 16 Nitrosoureas -- Section V: Antimetabolites -- 17 Antipurines -- 18 Ribofuranose-containing Analogues of Uridine and Cytidine -- 19 5-Halogenated Pyrimidines and Their Nucleosides -- 20 Resistance to Amino Acid Analogs -- 21 Alkaloids -- Section VI: Antifolates -- 22 Folate Antagonists -- 23 Steroids -- Section VII: Modification of Resistance -- 24 Collateral Sensitivity and Cross-Resistance.▲ | |
520 | ▼aThe study of tumour resistance to anticancer drugs has been the subject of many publications since the initial discovery of the phenomenon by J.H. Burchenal and colleagues in 1950. Many papers have been published since then reporting development of resistance to most of the well-known anticancer agents in many different animal tumour systems, both in vivo and in vitro. Many different mechanisms of resistance have been described, and it is clear that the tumour cell has a wide diversity of options in overcoming the cell-killing activity of these agents. Definition of the magnitude of the phenomenon in the clinic is, however, much more problematical, and it is with this in mind that the initial chapter, seeks to out line the problem as the clinicians see it. It appears that the phenomenon of true resistance to a drug, as the biochemist would recognise it, is an important cause of the failure which clinicians experience in treating the disease. The extent of the contribution of this phenomenon to the failure of treatment cannot easily be evaluated at the present time, but it is hoped that the development and application of new and more sophisticated techniques for the analysis of cellular sub populations may help to give a more exact estimate and to shed some light on the causes of failure of many of the present therapeutic techniques.▲ | ||
650 | 0 | ▼aMedicine.▲ | |
650 | 0 | ▼aToxicology.▲ | |
650 | 0 | ▼aPharmacy.▲ | |
650 | 0 | ▼aOncology.▲ | |
700 | 1 | ▼aFox, Margaret.▲ |
Antitumor Drug Resistance
자료유형
국외단행본
서명/책임사항
Antitumor Drug Resistance / edited by Brian W. Fox, Margaret Fox.
다양한 서명
With contributions by numerous experts
발행사항
Berlin, Heidelberg : Springer Berlin Heidelberg , 1984.
형태사항
XXV, 738 p. ; 25 cm.
내용주기
Section I: Concepts of Drug Resistance -- 1 Clinical Setting -- 2 Experimental Setting -- Section II: Modification of Host-Tumor Interaction -- 3 Drug Disposition and Pharmacology -- 4 Immunological Changes -- 5 The Molecular Basis of Genetically Acquired Resistance to Purine Analogues in Cultured Mammalian Cells -- Section III: Cellular Aspects -- 6 Cell Cycle Perturbation Effects -- 7 Tumour Resistance and the Phenomenon of Inflammatory-Cell Infiltration -- 8 Flow Cytometric Methods for Studying Enzyme Activity in Populations of Individual Cells -- 9 Chromosome Studies -- 10 Alterations of Drug Transport -- 11 Cell Hybridisation -- Section IV: Modification of Tumor Biochemistry -- 12 Drug Resistance and DNA Repair -- 13 Cyclic AMP and Prostaglandins -- 14 Properties of Mitochondria -- 15 Mechanism of "Resistance" Towards Specific Drug Groups -- 16 Nitrosoureas -- Section V: Antimetabolites -- 17 Antipurines -- 18 Ribofuranose-containing Analogues of Uridine and Cytidine -- 19 5-Halogenated Pyrimidines and Their Nucleosides -- 20 Resistance to Amino Acid Analogs -- 21 Alkaloids -- Section VI: Antifolates -- 22 Folate Antagonists -- 23 Steroids -- Section VII: Modification of Resistance -- 24 Collateral Sensitivity and Cross-Resistance.
요약주기
The study of tumour resistance to anticancer drugs has been the subject of many publications since the initial discovery of the phenomenon by J.H. Burchenal and colleagues in 1950. Many papers have been published since then reporting development of resistance to most of the well-known anticancer agents in many different animal tumour systems, both in vivo and in vitro. Many different mechanisms of resistance have been described, and it is clear that the tumour cell has a wide diversity of options in overcoming the cell-killing activity of these agents. Definition of the magnitude of the phenomenon in the clinic is, however, much more problematical, and it is with this in mind that the initial chapter, seeks to out line the problem as the clinicians see it. It appears that the phenomenon of true resistance to a drug, as the biochemist would recognise it, is an important cause of the failure which clinicians experience in treating the disease. The extent of the contribution of this phenomenon to the failure of treatment cannot easily be evaluated at the present time, but it is hoped that the development and application of new and more sophisticated techniques for the analysis of cellular sub populations may help to give a more exact estimate and to shed some light on the causes of failure of many of the present therapeutic techniques.
ISBN
9783642694929 3642694926
청구기호
615 F791a
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