소장자료
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001 | 0100801311▲ | ||
005 | 20240325091728▲ | ||
006 | m o d ▲ | ||
007 | cr#unu||||||||▲ | ||
008 | 240116s2023 us |||||||||||||||c||eng d▲ | ||
020 | ▼a9798380262132▲ | ||
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035 | ▼a(MiAaPQ)Pittsburgh44835▲ | ||
040 | ▼aMiAaPQ▼cMiAaPQ▲ | ||
082 | 0 | ▼a616▲ | |
100 | 1 | ▼aFowler, Erin.▲ | |
245 | 1 | 0 | ▼aBacteriophages Against Colistin-Resistant Klebsiella Pneumoniae▼h[electronic resource]▲ |
260 | ▼a[S.l.]: ▼bUniversity of Pittsburgh. ▼c2023▲ | ||
260 | 1 | ▼aAnn Arbor : ▼bProQuest Dissertations & Theses, ▼c2023▲ | |
300 | ▼a1 online resource(34 p.)▲ | ||
500 | ▼aSource: Dissertations Abstracts International, Volume: 85-03, Section: B.▲ | ||
500 | ▼aAdvisor: Mailliard, Robbie;Mattila, Joshua;Doi, Yohei.▲ | ||
502 | 1 | ▼aThesis (M.Sc.)--University of Pittsburgh, 2023.▲ | |
506 | ▼aThis item must not be sold to any third party vendors.▲ | ||
520 | ▼aKlebsiella pneumoniae is one of the most common causes of hospital-acquired infections, and is becoming increasingly resistant to various agents including colistin, a last resort antibiotic. As there are limited treatment options for these types of infections, bacteriophages active against them are drawing attention as a potential treatment option. To identify such bacteriophages, environmental water samples were screened against five different colistin-resistant clinical strains. As a result, two individual bacteriophages, MC8 and MC9, with activity against a colistin-resistant Klebsiella pneumoniae strain were isolated. Both bacteriophages were exclusively active againstK. pneumoniae Sequence Type (ST) 258 clade I strains, except for MC9, which was also active against an additional K. pneumoniae ST433 strain. Sequence analysis of the two bacteriophages showed identical sequences except for a 52 base pair nucleotide deletion in the tail spike gene in MC9. Generation of phage-resistant mutants to each bacteriophage was performed to identify their targets. Upon analysis of the phage-resistant mutant sequences, an insertion sequence was found in the wcaJgene encoding undecaprenyl-phosphate glucose-1-phosphage transferase. This gene helps catalyze the synthesis of colanic acid, a polysaccharide in the extracellular membrane, and a known attachment point used for phage entry.▲ | ||
590 | ▼aSchool code: 0178.▲ | ||
650 | 4 | ▼aGenetic testing.▲ | |
650 | 4 | ▼aInfections.▲ | |
650 | 4 | ▼aInfectious diseases.▲ | |
650 | 4 | ▼aPathogens.▲ | |
650 | 4 | ▼aAntibiotics.▲ | |
650 | 4 | ▼aMutation.▲ | |
650 | 4 | ▼aBacterial infections.▲ | |
650 | 4 | ▼aBacteria.▲ | |
650 | 4 | ▼aLawns.▲ | |
650 | 4 | ▼aFatty acids.▲ | |
650 | 4 | ▼aGlucose.▲ | |
650 | 4 | ▼aPublic health.▲ | |
650 | 4 | ▼aGenomes.▲ | |
650 | 4 | ▼aBiology.▲ | |
650 | 4 | ▼aProtozoa.▲ | |
650 | 4 | ▼aGram-negative bacteria.▲ | |
650 | 4 | ▼aResearch & development--R&D.▲ | |
650 | 4 | ▼aEnzymes.▲ | |
650 | 4 | ▼aDrug resistance.▲ | |
650 | 4 | ▼aGenetics.▲ | |
650 | 4 | ▼aMicrobiology.▲ | |
650 | 4 | ▼aPathology.▲ | |
650 | 4 | ▼aPharmaceutical sciences.▲ | |
650 | 4 | ▼aPharmacology.▲ | |
690 | ▼a0573▲ | ||
690 | ▼a0306▲ | ||
690 | ▼a0369▲ | ||
690 | ▼a0410▲ | ||
690 | ▼a0571▲ | ||
690 | ▼a0572▲ | ||
690 | ▼a0419▲ | ||
710 | 2 | 0 | ▼aUniversity of Pittsburgh.▲ |
773 | 0 | ▼tDissertations Abstracts International▼g85-03B.▲ | |
773 | ▼tDissertation Abstract International▲ | ||
790 | ▼a0178▲ | ||
791 | ▼aM.Sc.▲ | ||
792 | ▼a2023▲ | ||
793 | ▼aEnglish▲ | ||
856 | 4 | 0 | ▼uhttp://www.riss.kr/pdu/ddodLink.do?id=T16933762▼nKERIS▼z이 자료의 원문은 한국교육학술정보원에서 제공합니다.▲ |
Bacteriophages Against Colistin-Resistant Klebsiella Pneumoniae[electronic resource]
자료유형
국외eBook
서명/책임사항
Bacteriophages Against Colistin-Resistant Klebsiella Pneumoniae [electronic resource]
개인저자
발행사항
[S.l.] : University of Pittsburgh. 2023 Ann Arbor : ProQuest Dissertations & Theses , 2023
형태사항
1 online resource(34 p.)
일반주기
Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
Advisor: Mailliard, Robbie;Mattila, Joshua;Doi, Yohei.
Advisor: Mailliard, Robbie;Mattila, Joshua;Doi, Yohei.
학위논문주기
Thesis (M.Sc.)--University of Pittsburgh, 2023.
요약주기
Klebsiella pneumoniae is one of the most common causes of hospital-acquired infections, and is becoming increasingly resistant to various agents including colistin, a last resort antibiotic. As there are limited treatment options for these types of infections, bacteriophages active against them are drawing attention as a potential treatment option. To identify such bacteriophages, environmental water samples were screened against five different colistin-resistant clinical strains. As a result, two individual bacteriophages, MC8 and MC9, with activity against a colistin-resistant Klebsiella pneumoniae strain were isolated. Both bacteriophages were exclusively active againstK. pneumoniae Sequence Type (ST) 258 clade I strains, except for MC9, which was also active against an additional K. pneumoniae ST433 strain. Sequence analysis of the two bacteriophages showed identical sequences except for a 52 base pair nucleotide deletion in the tail spike gene in MC9. Generation of phage-resistant mutants to each bacteriophage was performed to identify their targets. Upon analysis of the phage-resistant mutant sequences, an insertion sequence was found in the wcaJgene encoding undecaprenyl-phosphate glucose-1-phosphage transferase. This gene helps catalyze the synthesis of colanic acid, a polysaccharide in the extracellular membrane, and a known attachment point used for phage entry.
주제
Genetic testing.
Infections.
Infectious diseases.
Pathogens.
Antibiotics.
Mutation.
Bacterial infections.
Bacteria.
Lawns.
Fatty acids.
Glucose.
Public health.
Genomes.
Biology.
Protozoa.
Gram-negative bacteria.
Research & development--R&D.
Enzymes.
Drug resistance.
Genetics.
Microbiology.
Pathology.
Pharmaceutical sciences.
Pharmacology.
Infections.
Infectious diseases.
Pathogens.
Antibiotics.
Mutation.
Bacterial infections.
Bacteria.
Lawns.
Fatty acids.
Glucose.
Public health.
Genomes.
Biology.
Protozoa.
Gram-negative bacteria.
Research & development--R&D.
Enzymes.
Drug resistance.
Genetics.
Microbiology.
Pathology.
Pharmaceutical sciences.
Pharmacology.
ISBN
9798380262132
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