소장자료
LDR | 04200cam a2200409 a 4500 | ||
001 | 0093409808▲ | ||
003 | OCoLC▲ | ||
005 | 20180519120737▲ | ||
008 | 150929s2015 sz a b 001 0 eng c▲ | ||
010 | ▼a2015943689▲ | ||
016 | 7 | ▼a101669283▼2DNLM▲ | |
020 | ▼a9783319187280 (alk. paper)▲ | ||
020 | ▼a3319187287 (alk. paper)▲ | ||
020 | ▼z9783319187297 (eBook)▲ | ||
035 | ▼a(OCoLC)907271740▲ | ||
040 | ▼aDNLM▼beng▼cNLM▼dYDXCP▼dOHX▼dUWO▼dOCLCF▼dXII▼dOCLCQ▼dOCLCO▲ | ||
042 | ▼apcc▲ | ||
050 | 4 | ▼aQH603.C43▼bN83 2015▲ | |
060 | 0 | 0 | ▼a2015 I-846▲ |
060 | 1 | 0 | ▼aQU 55.2▲ |
072 | 7 | ▼aQP▼2lcco▲ | |
082 | 0 | 4 | ▼a572.8▼223▲ |
090 | ▼a572.8▼bN964m▲ | ||
245 | 0 | 0 | ▼aNuclear receptors :▼bfrom structure to the clinic /▼cedited by Ian J. McEwan, Raj Kumar.▲ |
260 | ▼aCham :▼bSpringer,▼c2015.▲ | ||
300 | ▼axi, 236 p. :▼bill. ;▼c25 cm.▲ | ||
504 | ▼aIncludes bibliographical references and index.▲ | ||
505 | 0 | 0 | ▼tTwenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic /▼rIain J. McEwan and Raj Kumar --▼gPart I.▼tALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS.▼tCorticosteroid Receptors /▼rPeter J. Fuller, Jun Yang, and Morag J. Young --▼tGlucocorticoid Receptor Structure and Function /▼rRaj Kumar and Iain J. McEwan --▼tWhat Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors? /▼rVanessa Dubois [and 10 others] --▼tAllosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors /▼rJordan T. White [and 4 others] --▼tStructural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor /▼rMarek Orlowski [and 8 others] --▼tStructural Analysis of Heterodimeric Nuclear Receptors /▼rBrice Beinsteiner and Dino Moras --▼gPart II.▼tNUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS.▼tPrimate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11) /▼rElizabeth M. Wilson --▼tAssembly and Regulation of Nuclear Receptor Corepressor Complexes /▼rChristopher J. Millard and John W.R. Schwabe --▼gPart III.▼tTAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC --▼tThinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors /▼rNerea Gallastegui and Eva Estébanez-Perpiñá --▼tSelective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs) /▼rRamesh Narayanan and James T. Dalton.▲ |
520 | ▼a"Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. The aim is to bring together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors"--Back cover.▲ | ||
650 | 0 | ▼aNuclear receptors (Biochemistry)▲ | |
650 | 0 | ▼aHuman genome.▲ | |
650 | 1 | 2 | ▼aReceptors, Cytoplasmic and Nuclear▼xphysiology.▲ |
650 | 1 | 2 | ▼aReceptors, Cytoplasmic and Nuclear▼xchemistry.▲ |
650 | 2 | 2 | ▼aStructure-Activity Relationship.▲ |
700 | 1 | ▼aMcEwan, I. J.▲ | |
700 | 1 | ▼aKumar, Raj.▲ | |
999 | ▼c김정이▲ |
Nuclear receptors :from structure to the clinic
자료유형
국외단행본
서명/책임사항
Nuclear receptors : from structure to the clinic / edited by Ian J. McEwan, Raj Kumar.
발행사항
Cham : Springer , 2015.
형태사항
xi, 236 p. : ill. ; 25 cm.
서지주기
Includes bibliographical references and index.
내용주기
Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic / Iain J. McEwan and Raj Kumar -- Part I. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. Corticosteroid Receptors / Peter J. Fuller, Jun Yang, and Morag J. Young -- Glucocorticoid Receptor Structure and Function / Raj Kumar and Iain J. McEwan -- What Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors? / Vanessa Dubois [and 10 others] -- Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors / Jordan T. White [and 4 others] -- Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor / Marek Orlowski [and 8 others] -- Structural Analysis of Heterodimeric Nuclear Receptors / Brice Beinsteiner and Dino Moras -- Part II. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS. Primate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11) / Elizabeth M. Wilson -- Assembly and Regulation of Nuclear Receptor Corepressor Complexes / Christopher J. Millard and John W.R. Schwabe -- Part III. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC -- Thinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors / Nerea Gallastegui and Eva Estébanez-Perpiñá -- Selective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs) / Ramesh Narayanan and James T. Dalton.
요약주기
"Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. The aim is to bring together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors"--Back cover.
주제
ISBN
9783319187280 (alk. paper) 3319187287 (alk. paper)
청구기호
572.8 N964m
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