학술논문
Experimental model of intracranial hypertension with continuous multiparametric monitoring in swine
Document Type
article
Author
Andrade, Almir Ferreira de; Soares, Matheus Schmidt; Patriota, Gustavo Cartaxo; Belon, Alessandro Rodrigo; Paiva, Wellingson Silva; Bor-Seng-Shu, Edson; Oliveira, Marcelo de Lima; Nascimento, Clarissa Nobrega; Noleto, Gustavo Sousa; Alves Junior, Aderaldo Costa; Figueiredo, Eberval Gadelha; Otoch, Jose Pinhata; Teixeira, Manoel Jacobsen
Source
Arquivos de Neuro-Psiquiatria. October 2013 71(10)
Subject
Language
English
ISSN
0004-282X
Abstract
Objective Intracranial hypertension (IH) develops in approximately 50% of all patients with severe traumatic brain injury (TBI). Therefore, it is very important to identify a suitable animal model to study and understand the pathophysiology of refractory IH to develop effective treatments. Methods We describe a new experimental porcine model designed to simulate expansive brain hematoma causing IH. Under anesthesia, IH was simulated with a balloon insufflation. The IH variables were measured with intracranial pressure (ICP) parenchymal monitoring, epidural, cerebral oximetry, and transcranial Doppler (TCD). Results None of the animals died during the experiment. The ICP epidural showed a slower rise compared with parenchymal ICP. We found a correlation between ICP and cerebral oximetry. Conclusion The model described here seems useful to understand some of the pathophysiological characteristics of acute IH.