학술논문
Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose
Document Type
article
Author
Wu, Peitao; Rybin, Denis; Bielak, Lawrence F; Feitosa, Mary F; Franceschini, Nora; Li, Yize; Lu, Yingchang; Marten, Jonathan; Musani, Solomon K; Noordam, Raymond; Raghavan, Sridharan; Rose, Lynda M; Schwander, Karen; Smith, Albert V; Tajuddin, Salman M; Vojinovic, Dina; Amin, Najaf; Arnett, Donna K; Bottinger, Erwin P; Demirkan, Ayse; Florez, Jose C; Ghanbari, Mohsen; Harris, Tamara B; Launer, Lenore J; Liu, Jingmin; Liu, Jun; Mook-Kanamori, Dennis O; Murray, Alison D; Nalls, Mike A; Peyser, Patricia A; Uitterlinden, André G; Voortman, Trudy; Bouchard, Claude; Chasman, Daniel; Correa, Adolfo; de Mutsert, Renée; Evans, Michele K; Gudnason, Vilmundur; Hayward, Caroline; Kao, Linda; Kardia, Sharon LR; Kooperberg, Charles; Loos, Ruth JF; Province, Michael M; Rankinen, Tuomo; Redline, Susan; Ridker, Paul M; Rotter, Jerome I; Siscovick, David; Smith, Blair H; van Duijn, Cornelia; Zonderman, Alan B; Rao, DC; Wilson, James G; Dupuis, Josée; Meigs, James B; Liu, Ching-Ti; Vassy, Jason L
Source
PLOS ONE. 15(5)
Subject
Language
Abstract
Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction studies to identify loci exhibiting potential interaction with baseline smoking status (ever vs. never) on incident T2D and fasting glucose (FG). Analyses were performed in participants of European (EA) and African ancestry (AA) separately. Discovery analyses were conducted using genotype data from the 50,000-single-nucleotide polymorphism (SNP) ITMAT-Broad-CARe (IBC) array in 5 cohorts from from the Candidate Gene Association Resource Consortium (n = 23,189). Replication was performed in up to 16 studies from the Cohorts for Heart Aging Research in Genomic Epidemiology Consortium (n = 74,584). In meta-analysis of discovery and replication estimates, 5 SNPs met at least one criterion for potential interaction with smoking on incident T2D at p