학술논문
MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma
Document Type
article
Author
Kang, Eun Young; Millstein, Joshua; Popovic, Gordana; Meagher, Nicola S; Bolithon, Adelyn; Talhouk, Aline; Chiu, Derek S; Anglesio, Michael S; Leung, Betty; Tang, Katrina; Lambie, Neil; Pavanello, Marina; Da-anoy, Annalyn; Lambrechts, Diether; Loverix, Liselore; Olbrecht, Siel; Bisinotto, Christiani; Garcia-Donas, Jesus; Ruiz-Llorente, Sergio; Yagüe-Fernandez, Monica; Edwards, Robert P; Elishaev, Esther; Olawaiye, Alexander; Taylor, Sarah; Ataseven, Beyhan; du Bois, Andreas; Harter, Philipp; Lester, Jenny; Høgdall, Claus K; Armasu, Sebastian M; Huang, Yajue; Vierkant, Robert A; Wang, Chen; Winham, Stacey J; Heublein, Sabine; Kommoss, Felix KF; Cramer, Daniel W; Sasamoto, Naoko; van-Wagensveld, Lilian; Lycke, Maria; Mateoiu, Constantina; Joseph, Janine; Pike, Malcolm C; Odunsi, Kunle; Tseng, Chiu-Chen; Pearce, Celeste L; Bilic, Sanela; Conrads, Thomas P; Hartmann, Arndt; Hein, Alexander; Jones, Michael E; Leung, Yee; Beckmann, Matthias W; Ruebner, Matthias; Schoemaker, Minouk J; Terry, Kathryn L; El-Bahrawy, Mona A; Coulson, Penny; Etter, John L; LaVigne-Mager, Katherine; Andress, Juergen; Grube, Marcel; Fischer, Anna; Neudeck, Nina; Robertson, Greg; Farrell, Rhonda; Barlow, Ellen; Quinn, Carmel; Hettiaratchi, Anusha; Casablanca, Yovanni; Erber, Ramona; Stewart, Colin JR; Tan, Adeline; Yu, Yu; Boros, Jessica; Brand, Alison H; Harnett, Paul R; Kennedy, Catherine J; Nevins, Nikilyn; Morgan, Terry; Fasching, Peter A; Vergote, Ignace; Swerdlow, Anthony J; Candido dos Reis, Francisco J; Maxwell, G Larry; Neuhausen, Susan L; Barquin-Garcia, Arantzazu; Modugno, Francesmary; Moysich, Kirsten B; Crowe, Philip J; Hirasawa, Akira; Heitz, Florian; Karlan, Beth Y; Goode, Ellen L; Sinn, Peter; Horlings, Hugo M; Høgdall, Estrid; Sundfeldt, Karin; Kommoss, Stefan; Staebler, Annette
Source
Virchows Archiv. 480(4)
Subject
Language
Abstract
Tubo-ovarian high-grade serous carcinomas (HGSC) are highly proliferative neoplasms that generally respond well to platinum/taxane chemotherapy. We recently identified minichromosome maintenance complex component 3 (MCM3), which is involved in the initiation of DNA replication and proliferation, as a favorable prognostic marker in HGSC. Our objective was to further validate whether MCM3 mRNA expression and possibly MCM3 protein levels are associated with survival in patients with HGSC. MCM3 mRNA expression was measured using NanoString expression profiling on formalin-fixed and paraffin-embedded tissue (N = 2355 HGSC) and MCM3 protein expression was assessed by immunohistochemistry (N = 522 HGSC) and compared with Ki-67. Kaplan-Meier curves and the Cox proportional hazards model were used to estimate associations with survival. Among chemotherapy-naïve HGSC, higher MCM3 mRNA expression (one standard deviation increase in the score) was associated with longer overall survival (HR = 0.87, 95% CI 0.81-0.92, p