학술논문
Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes.
Document Type
article
Author
Gagliardi, Alessia; Porter, Vanessa L; Zong, Zusheng; Bowlby, Reanne; Titmuss, Emma; Namirembe, Constance; Griner, Nicholas B; Petrello, Hilary; Bowen, Jay; Chan, Simon K; Culibrk, Luka; Darragh, Teresa M; Stoler, Mark H; Wright, Thomas C; Gesuwan, Patee; Dyer, Maureen A; Ma, Yussanne; Mungall, Karen L; Jones, Steven JM; Nakisige, Carolyn; Novik, Karen; Orem, Jackson; Origa, Martin; Gastier-Foster, Julie M; Yarchoan, Robert; Casper, Corey; Mills, Gordon B; Rader, Janet S; Ojesina, Akinyemi I; Gerhard, Daniela S; Mungall, Andrew J; Marra, Marco A
Source
Nature genetics. 52(8)
Subject
Language
Abstract
Cervical cancer is the most common cancer affecting sub-Saharan African women and is prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer genomes, transcriptomes or epigenomes has been performed in this population thus far. We characterized 118 tumors from Ugandan patients, of whom 72 were HIV+, and performed extended mutation analysis on an additional 89 tumors. We detected human papillomavirus (HPV)-clade-specific differences in tumor DNA methylation, promoter- and enhancer-associated histone marks, gene expression and pathway dysregulation. Changes in histone modification at HPV integration events were correlated with upregulation of nearby genes and endogenous retroviruses.