학술논문
Subgroup and subtype-specific outcomes in adult medulloblastoma.
Document Type
article
Author
Tirapelli, Daniela; Carlotti, Carlos; Li, Kay; Ryzhova, Marina; Golanov, Andrey; Zheludkova, Olga; Absalyamova, Oksana; Okonechnikov, Konstantin; Stichel, Damian; von Deimling, Andreas; Giannini, Caterina; Raskin, Scott; Van Meir, Erwin; Chan, Jennifer; Fults, Daniel; Chambless, Lola; Kim, Seung-Ki; Vasiljevic, Alexandre; Faure-Conter, Cecile; Vibhakar, Rajeev; Jung, Shin; Leary, Sarah; Mora, Jaume; McLendon, Roger; Pollack, Ian; Hauser, Peter; Grajkowska, Wieslawa; Rubin, Joshua; van Veelen, Marie-Lise; French, Pim; Kros, Johan; Coltin, Hallie; Sundaresan, Lakshmikirupa; Smith, Kyle; Skowron, Patryk; Massimi, Luca; Eberhart, Charles; Schreck, Karisa; Gupta, Nalin; Pfister, Stefan; Kool, Marcel; Kijima, Noriyuki; Taylor, Michael; Packer, Roger; Northcott, Paul; Korshunov, Andrey; Ramaswamy, Vijay; Weiss, William; Liau, Linda
Source
Acta Neuropathologica. 142(5)
Subject
Language
Abstract
Medulloblastoma, a common pediatric malignant central nervous system tumour, represent a small proportion of brain tumours in adults. Previously it has been shown that in adults, Sonic Hedgehog (SHH)-activated tumours predominate, with Wingless-type (WNT) and Group 4 being less common, but molecular risk stratification remains a challenge. We performed an integrated analysis consisting of genome-wide methylation profiling, copy number profiling, somatic nucleotide variants and correlation of clinical variables across a cohort of 191 adult medulloblastoma cases identified through the Medulloblastoma Advanced Genomics International Consortium. We identified 30 WNT, 112 SHH, 6 Group 3, and 41 Group 4 tumours. Patients with SHH tumours were significantly older at diagnosis compared to other subgroups (p