학술논문
Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results from the ICONIC study
Document Type
article
Author
Conte, Edoardo; Dwivedi, Aeshita; Mushtaq, Saima; Pontone, Gianluca; Lin, Fay Y; Hollenberg, Emma J; Lee, Sang-Eun; Bax, Jeroen; Cademartiri, Filippo; Chinnaiyan, Kavitha; Chow, Benjamin JW; Cury, Ricardo C; Feuchtner, Gudrun; Hadamitzky, Martin; Kim, Yong-Jin; Baggiano, Andrea; Leipsic, Jonathon; Maffei, Erica; Marques, Hugo; Plank, Fabian; Raff, Gilbert L; van Rosendael, Alexander R; Villines, Todd C; Weirich, Harald G; Al’Aref, Subhi J; Baskaran, Lohendran; Cho, Iksung; Danad, Ibrahim; Han, Donghee; Heo, Ran; Lee, Ji Hyun; Stuijfzand, Wijnand J; Gransar, Heidi; Lu, Yao; Sung, Ji Min; Park, Hyung-Bok; Al-Mallah, Mouaz H; de Araújo Gonçalves, Pedro; Berman, Daniel S; Budoff, Matthew J; Samady, Habib; Shaw, Leslee J; Stone, Peter H; Virmani, Renu; Narula, Jagat; Min, James K; Chang, Hyuk-Jae; Andreini, Daniele
Source
European Heart Journal - Cardiovascular Imaging. 22(1)
Subject
Language
Abstract
AimsAlthough there is increasing evidence supporting coronary atherosclerosis evaluation by coronary computed tomography angiography (CCTA), no data are available on age and sex differences for quantitative plaque features. The aim of this study was to investigate sex and age differences in both qualitative and quantitative atherosclerotic features from CCTA prior to acute coronary syndrome (ACS).Methods and resultsWithin the ICONIC study, in which 234 patients with subsequent ACS were propensity matched 1:1 with 234 non-event controls, our current subanalysis included only the ACS cases. Both qualitative and quantitative advance plaque analysis by CCTA were performed by a core laboratory. In 129 cases, culprit lesions identified by invasive coronary angiography at the time of ACS were co-registered to baseline CCTA precursor lesions. The study population was then divided into subgroups according to sex and age (