학술논문
HIV-1 drug resistance before initiation or re-initiation of first-line ART in eight regions of Mexico: a sub-nationally representative survey
Document Type
article
Author
Ávila-Ríos, Santiago; García-Morales, Claudia; Valenzuela-Lara, Marisol; Chaillon, Antoine; Tapia-Trejo, Daniela; Pérez-García, Marissa; López-Sánchez, Dulce M; Maza-Sánchez, Liliana; del Arenal-Sánchez, Silvia J; Paz-Juárez, Héctor E; Quiroz-Morales, Verónica S; Mehta, Sanjay R; Smith, David M; León-Juárez, Eddie A; Magis-Rodríguez, Carlos; Reyes-Terán, Gustavo; Gamboa-Marroquín, Jorge A; Espinoza-Fernández, Alan F; Lam-Enríquez, Mario; Castillo-Soria, Oscar A; Navarro-Álvarez, Samuel; Varela-Lara, Noemí; Ortiz-Batanero, Rogelio; Flores-Gómez, Andrés; Velasco-Robledo, Luis; Alatorre-Manjarrez, Arturo; Gutiérrez-Zúñiga, Rita E; Peña-Gutiérrez, Jesús; Rivera-Marroquín, Alejandro; Robles, Berenice; Gálvez-Martínez, Maribel; Hernández-Gutiérrez, Raúl; Solís-Grajales, David; Mora-Castellanos, María G; Vidal-López, Manuel; González-Pacheco, Maribel A; Salazar-Pérez, Carmen; Padilla-Acosta, Juan CA; González-Rodríguez, Andrea; Badial-Hernández, Florentino; Tecalero-Hernández, José C; García-Martínez, Patricia G; Cendejas-Hernández, Arturo; Mosqueda-Gómez, Juan L; Benítez-Carrasco, José M; Bello, José L Sánchez; Fierro-Teliz, Benjamín; Arellano-Torreblanca, Jazmín; Manríquez-Gómez, Ramiro; Zaragoza-Zapata, Elizabeth; Ruiz-Torrez, Saúl O; González-Hernández, Luz A; Soria-Rodríguez, Raúl; Quintero-Pérez, Nora P; Amaya-Tapia, Gerardo; Arredondo-Fuentes, Juana; Santiesteban-Garay, Javier; Mendoza-García, María S; Durán-Arias, Gustavo; Rosas-Dossetti, Margarita M; Chacón-Sánchez, Juana C; Uribe-Iturbide, Angélica; Castro-Melchor, Pedro; Castillo-Reyna, Luis G; Rivera-Abarca, Lesvia M; de la Cruz-Castillo, Jorge E; Papaqui-Limón, Elizabeth; Velázquez-Esqueda, María P; Domínguez-Sánchez, Alexandra S; Magdaleno-Sandoval, Zoila; Silva-Herrera, Jorge; Esparza-Pérez, Mario A; Muñoz-Doana, Alejandro; Aldapa, Gabriela; Arrollo-Romero, Fernando; Salazar-Arriola, Sergio A; Vásquez-Bañuelos, Elva C; Hernández-Morales, Mario J; Prado-Rosas, Daniel; Santos-Villegas, Mercedes; Sánchez-Hernández, Esteban; Jiménez-Jiménez, Adonay; Cárdenas-Anzures, Alejandro; Ortiz-Brisuela, Juan F; Díaz-García, Juana; Carrillo-Garza, Carlos A; Beltrán-Saldaña, Juan; Sánchez-Rivas, Santos; Domínguez-Ramírez, Lizbeth; de la Roca-Chiapas, Jorge M; Basilio-Badillo, Hilda; Torruco-García, Uri; Pérez-Alonso, Juan A; Arias-Tlacuilo, Luis E; Palacios-Lara, Omar
Source
Journal of Antimicrobial Chemotherapy. 74(4)
Subject
Language
Abstract
BackgroundHIV pretreatment drug resistance (PDR) to NNRTIs in persons initiating ART is increasing in Mexico.ObjectivesTo compare HIV PDR in eight sub-regions of Mexico.Patients and methodsA large PDR survey was implemented in Mexico (September 2017-March 2018) across eight sub-regions. All larger clinics (which provide ART to 90% of all initiators) were included, allocating sample size using the probability-proportional-to-size method. Both antiretroviral-naive and prior antiretroviral-exposed persons were included. HIV PDR levels were estimated from pol Sanger sequences obtained at a WHO-designated laboratory.ResultsA total of 2006 participants were enrolled from 74 clinics. PDR to NNRTIs was higher than to other drug classes (P