학술논문
Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non–rheumatoid arthritis controls
Document Type
Academic Journal
Author
Source
Arthritis & Rheumatism. Mar 01, 2013 65(3):571-581
Subject
Language
English
ISSN
0004-3591
Abstract
OBJECTIVE.: METHODS.: RESULTS.: The mean ages were 60.7 years in RA cases and 64.6 years in non-RA controls. The proportion of female subjects was 79% in each group. The prevalence of ACPAs and ANAs was higher in RA cases compared to controls (each P < 0.0001); there were no differences in the prevalence of anti-TPO antibodies and AGTAs. Carriage of higher numbers of autoimmune risk alleles was associated with increasing numbers of autoantibody types in RA cases (P = 2.1 × 10) and non-RA controls (P = 5.0 × 10). From the PheWAS, the presence of ANAs was significantly associated with a diagnosis of Sjögrenʼs/sicca syndrome in RA cases. CONCLUSION.