학술논문
Multimodal evoked potentials to assess the evolution of multiple sclerosis: a longitudinal study
Document Type
Academic Journal
Author
Source
JOURNAL OF NEUROLOGY, NEUROSURGERY, & PSYCHIATRY. Sep 01, 2006 77(9):1030-1035
Subject
Language
English
ISSN
0022-3050
Abstract
BACKGROUND:: Evoked potentials are used in the functional assessment of sensory and motor pathways. Their usefulness in monitoring the evolution of multiple sclerosis has not been fully clarified. OBJECTIVE:: The aim of this longitudinal study was to examine the usefulness of multimodal evoked potential in predicting paraclinical outcomes of disease severity and as a prognostic marker in multiple sclerosis. METHODS:: Eighty four patients with clinically definite multiple sclerosis underwent Expanded Disability Status Scale (EDSS) and functional system scoring at study entry and after a mean (standard deviation) follow-up of 30.5 (11.7) months. Sensory and motor evoked potentials were obtained in all patients at study entry and at follow-up in 64 of them, and quantified according to a conventional score. RESULTS:: Cross-sectionally, the severity of each evoked potential score significantly correlated with the corresponding functional system (0.32