학술논문
Total Cholesterol Level for Assessing Pancreatic Insufficiency Due to Chronic Pancreatitis
Document Type
Article
Author
Kenji Hirano; Tomotaka Saito; Suguru Mizuno; Minoru Tada; Naoki Sasahira; Hiroyuki Isayama; Miho Matsukawa; Gyotane Umefune; Dai Akiyama; Kei Saito; Shuhei Kawahata; Naminatsu Takahara; Rie Uchino; Tsuyoshi Hamada; Koji Miyabayashi; Dai Mohri; Takashi Sasaki; Hirofumi Kogure; Natsuyo Yamamoto; Yosuke Nakai; Kazuhiko Koike
Source
Gut and Liver. Sep 30, 2014 8(5):563
Subject
Language
English
ISSN
1976-2283
Abstract
Background/Aims: To determine the nutritional markers important for assessing the degree of pancreatic insufficiency due to chronic pancreatitis in routine clinical practice. Methods: A total of 137 patients with chronic pancreatitis were followed up for more than 1 year. They were divided into two groups: a pancreatic diabetes mellitus (DM) group, consisting of 47 patients undergoing medical treatment for DM of pancreatic origin, and a nonpancreatic DM group, consisting of 90 other patients (including 86 patients without DM). Serum albumin, prealbumin, total cholesterol, cholinesterase, magnesium, and hemoglobin were compared between the two groups. Results: The total cholesterol was significantly lower in the pancreatic than the nonpancreatic DM group (164 mg/dL vs 183 mg/dL, respectively; p=0.0028). Cholinesterase was significantly lower in the former group (263 U/L vs 291 U/L, respectively; p=0.016). Among the 37 patients with nonalcoholic pancreatitis, there was no difference in the cholinesterase levels between the pancreatic and nonpancreatic (296 U/L vs 304 U/L, respectively; p=0.752) DM groups, although cholesterol levels remained lower in the former (165 mg/dL vs 187 mg/dL, respectively; p=0.052). Conclusions: Cholinesterase levels are possibly affected by concomitant alcoholic liver injury. The total cholesterol level should be considered when assessing pancreatic insufficiency due to chronic pancreatitis. (Gut Liver 2014;8:563-568)