학술논문
마이코플라스마 폐렴에서 나타나는 폐외 증상의 발생률과 위험 인자
The incidence and risk factors of extrapulmonary manifestations in Mycoplasma pneumoniae pneumonia
The incidence and risk factors of extrapulmonary manifestations in Mycoplasma pneumoniae pneumonia
Document Type
Article
Author
박유경 / Yoo Kyung Park; 박유나 / You Na Park; 문지은 / Ji Eun Moon; 김효빈 / Hyo-bin Kim; 신미용 / Meeyong Shin; 이은 / Eun Lee; 김철홍 / Chul-hong Kim; 이주석 / Ju Suk Lee; 이용주 / Yong Ju Lee; 김봉성 / Bong-seong Kim; 김형영 / Hyung Young Kim; 정성수 / Sungsu Jung; 김윤선 / Yunsun Kim; 김상영 / Sangyoung Kim; 박초롱 / Chorong Park; 서주희 / Ju-hee Seo; 심정연 / Jung Yeon Shim; 설인숙 / In Suk Sol; 성명순 / Myongsoon Sung; 송대진 / Dae Jin Song; 안영민 / Young Min Ahn; 오혜린 / Hea Lin Oh; 유진호 / Jinho Yu; 이경석 / Kyung Suk Lee; 장광천 / Gwang Cheon Jang; 장윤영 / Yoon-young Jang; 정혜리 / Hai Lee Chung; 정은희 / Eun Hee Chung; 최성민 / Sung-min Choi; 최윤정 / Yun Jung Choi; 한만용 / Man Yong Han; 김진택 / Jin Tack Kim; 김창근 / Chang-keun Kim; 양현종 / Hyeon-jong Yang
Source
Allergy asthma & respiratory disease. Oct 30, 2022 10(4):207
Subject
Language
Korean
ISSN
2288-0402
Abstract
Purpose: Mycoplasma pneumoniae pneumonia (MP) is a major cause of community-acquired pneumonia (CAP) in children and is associated with extrapulmonary manifestations (EPM). The incidence and risk factors for EPM in children are unknown. Methods: This was a retrospective study involving 65,243 pediatric patients with CAP between 2010 and 2015 at 23 nationwide hospitals in South Korea. Medical records were reviewed to collect information regarding the clinical characteristics, radiological results, and laboratory findings. Logistic regression with multivariate analysis was performed to evaluate the risk factors associated with EPM in MP. Results: The incidence of EPM was 23.9%, including elevation of liver enzymes (18.1%), mucocutaneous manifestations (4.4%), proteinuria (4.1%), cardiovascular and neurological manifestations (0.4%), hematologic manifestations (0.2%), and arthritis (0.2%). Statistical analysis showed that mucocutaneous manifestations significantly increased with elevated alanine aminotransferase (adjusted odds ratio [aOR], 3.623; 95% confidence interval [CI], 1.933-6.790) and atopic sensitization (aOR, 2.973; 95% CI, 1.615-5.475) and decreased with respiratory virus coinfection (aOR, 0.273; 95% CI, 0.084-0.887). Elevated liver enzymes were significantly associated with elevated lactate dehydrogenase (aOR, 3.055; 95% CI, 2.257-4.137), presence of pleural effusion (aOR, 2.635; 95% CI, 1.767-3.930), and proteinuria with respiratory virus coinfection (aOR, 2.245; 95% CI, 1.113-4.527). Conclusion: Approximately 24% of pediatric patients with MP had various EPM. As the risk factors associated with each EPM were different, it is necessary to evaluate the various clinical aspects and findings of MP to predict and prepare for the occurrence of EPM. (Allergy Asthma Respir Dis 2022;10:207-214)