학술논문
A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function
Document Type
Academic Journal
Author
Source
Cell. Sept 19, 1997, Vol. 90 Issue 6, p1149, 11 p.
Subject
Language
ISSN
0092-8674
Abstract
Rab5, a small GTPase, is important in endocytic traffic processes. A novel 60 kDA Rab5-binding protein Rabex-5 has been determined. It forms a tight physical complex with Rabaptin-5 which is essential for endocytic membrane fusion. Nanoelectrospray mass spectrometry and cloning to sequence the mammalian Rabex-5, revealed a striking homology to the yeast protein Vps9p, implicated in endocytic traffic.