학술논문
TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
Meta-Analysiz
Meta-Analysiz
Document Type
Medical condition overview
Author
Osinga, Joris A.J.; Derakhshan, Arash; Palomaki, Glenn E.; Ashoor, Ghalia; Mannisto, Tuija; Maraka, Spyridoula; Chen, Liangmiao; Bliddal, Sofie; Lu, Xuemian; Taylor, Peter N.; Vrijkotte, Tanja G.M.; Tao, Fang-Biao; Brown, Suzanne J.; Ghafoor, Farkhanda; Poppe, Kris; Veltri, Flora; Chatzi, Lida; Vaidya, Bijay; Broeren, Maarten A.C.; Shields, Beverley M.; Itoh, Sachiko; Mosso, Lorena; Popova, Polina V.; Anopova, Anna D.; Kishi, Reiko; Aminorroaya, Ashraf; Kianpour, Maryam; Lopez-Bermejo, Abel; Oken, Emily; Pirzada, Amna; Vafeiadi, Marina; Bramer, Wichor M.; Suvanto, Eila; Yoshinaga, Jun; Huang, Kun; Bassols, Judit; Boucai, Laura; Feldt-Rasmussen, Ulla; Grineva, Elena N.; Pearce, Elizabeth N.; Alexander, Erik K.; Pop, Victor J.M.; Nelson, Scott M.; Walsh, John P.; Peeters, Robin P.; Chaker, Layal; Nicolaides, Kypros H.; DAlton, Mary E.; Korevaar, Tim I.M.
Source
Journal of Clinical Endocrinology & Metabolism. October 2022, Vol. 107 Issue 10, p2925, 9 p.
Subject
Language
English
ISSN
0021-972X
Abstract
Adequate thyroid hormone availability during pregnancy is important for an uncomplicated pregnancy as well as optimal fetal growth and development. Thyroid function test abnormalities during pregnancy are associated with a [...]
Context: Interpretation of thyroid function tests during pregnancy is limited by the generalizability of reference intervals between cohorts due to inconsistent methodology. Objective: (1) To provide an overview of published reference intervals for thyrotropin (TSH) and free thyroxine (FT4) in pregnancy, (2) to assess the consequences of common methodological between-study differences by combining raw data from different cohorts. Methods: (1) Ovid MEDLINE, EMBASE, and Web of Science were searched until December 12, 2021. Studies were assessed in duplicate. (2) The individual participant data (IPD) meta-analysis was performed in participating cohorts in the Consortium on Thyroid and Pregnancy. Results: (1) Large between-study methodological differences were identified, 11 of 102 included studies were in accordance with current guidelines; (2) 22 cohorts involving 63 198 participants were included in the meta-analysis. Not excluding thyroid peroxidase antibody--positive participants led to a rise in the upper limits of TSH in all cohorts, especially in the first (mean +17.4%; range +1.6 to +30.3%) and second trimester (mean +9.8%; range +0.6 to +32.3%). The use of the 95th percentile led to considerable changes in upper limits, varying from -10.8% to -21.8% for TSH and -1.2% to -13.2% for FT4. All other additional exclusion criteria changed reference interval cut-offs by a maximum of 3.5%. Applying these findings to the 102 studies included in the systematic review, 48 studies could be used in a clinical setting. Conclusion: We provide an overview of clinically relevant reference intervals for TSH and FT4 in pregnancy. The results of the meta-analysis indicate that future studies can adopt a simplified study setup without additional exclusion criteria. Key Words: thyroid, pregnancy, reference values, thyrotropin (TSH), free thyroxine (FT4) Abbreviations: ATA, American Thyroid Association; BMI, body mass index; FT4, free thyroxine; IPD, individual patient data; IVF, in vitro fertilization; SGA, small for gestational age; TgAb, thyroglobulin antibody; TPOAb, thyroid peroxidase antibody; TSH, thyrotropin.
Context: Interpretation of thyroid function tests during pregnancy is limited by the generalizability of reference intervals between cohorts due to inconsistent methodology. Objective: (1) To provide an overview of published reference intervals for thyrotropin (TSH) and free thyroxine (FT4) in pregnancy, (2) to assess the consequences of common methodological between-study differences by combining raw data from different cohorts. Methods: (1) Ovid MEDLINE, EMBASE, and Web of Science were searched until December 12, 2021. Studies were assessed in duplicate. (2) The individual participant data (IPD) meta-analysis was performed in participating cohorts in the Consortium on Thyroid and Pregnancy. Results: (1) Large between-study methodological differences were identified, 11 of 102 included studies were in accordance with current guidelines; (2) 22 cohorts involving 63 198 participants were included in the meta-analysis. Not excluding thyroid peroxidase antibody--positive participants led to a rise in the upper limits of TSH in all cohorts, especially in the first (mean +17.4%; range +1.6 to +30.3%) and second trimester (mean +9.8%; range +0.6 to +32.3%). The use of the 95th percentile led to considerable changes in upper limits, varying from -10.8% to -21.8% for TSH and -1.2% to -13.2% for FT4. All other additional exclusion criteria changed reference interval cut-offs by a maximum of 3.5%. Applying these findings to the 102 studies included in the systematic review, 48 studies could be used in a clinical setting. Conclusion: We provide an overview of clinically relevant reference intervals for TSH and FT4 in pregnancy. The results of the meta-analysis indicate that future studies can adopt a simplified study setup without additional exclusion criteria. Key Words: thyroid, pregnancy, reference values, thyrotropin (TSH), free thyroxine (FT4) Abbreviations: ATA, American Thyroid Association; BMI, body mass index; FT4, free thyroxine; IPD, individual patient data; IVF, in vitro fertilization; SGA, small for gestational age; TgAb, thyroglobulin antibody; TPOAb, thyroid peroxidase antibody; TSH, thyrotropin.