학술논문
A prospective follow-up of thyroid volume and thyroiditis features on ultrasonography among survivors of predominantly mild to moderate COVID-19
Document Type
Academic Journal
Author
Fung, Man Him Matrix; Lui, David Tak Wai; Chiu, Keith Wan Hang; Lee, Sherman Haynam; Lee, Chi Ho; Chow, Wing Sun; Lee, Alan Chun Hong; Tam, Anthony Raymond; Pang, Polly; Ho, Tip Yin; Fong, Carol Ho Yi; Loong, Connie Hong Nin; Law, Chun Yiu; To, Kelvin Kai Wang; Lam, Ching Wan; Tan, Kathryn Choon Beng; Woo, Yu Cho; Hung, Ivan Fan Ngai; Lam, Karen Siu Ling; Lang, Brian
Source
PeerJ. March 17, 2023, Vol. 11 e15034
Subject
Language
English
ISSN
2167-8359
Abstract
Background We previously showed that higher SARS-CoV-2 viral load correlated with smaller thyroid volumes among COVID-19 survivors at 2 months after acute COVID-19. Our current follow-up study evaluated the evolution of thyroid volumes and thyroiditis features within the same group of patients 6 months later. Methods Adult COVID-19 survivors who underwent thyroid ultrasonography 2 months after infection (USG1) were recruited for follow-up USG 6 months later (USG2). The primary outcome was the change in thyroid volume. We also reassessed thyroiditis features on USG, thyroid function and anti-thyroid antibodies. Results Fifty-four patients were recruited (mean age 48.1 years; 63% men). The mean thyroid volume increased from USG1 to USG2 (11.9 ± 4.8 to 14.5 ± 6.2 mL, p Conclusion Most COVID-19 survivors had an increase in thyroid volume from early convalescent phase to later convalescent phase. This increase correlated with high initial SARS-CoV-2 viral load. Together with the resolution of thyroiditis features, these may suggest a transient direct atrophic effect of SARS-CoV-2 on the thyroid gland with subsequent recovery of thyroid volume and thyroiditis features.
Author(s): Man Him Matrix Fung (1,*), David Tak Wai Lui (2,*), Keith Wan Hang Chiu (3), Sherman Haynam Lee (1), Chi Ho Lee (2), Wing Sun Chow (2), Alan Chun [...]
Author(s): Man Him Matrix Fung (1,*), David Tak Wai Lui (2,*), Keith Wan Hang Chiu (3), Sherman Haynam Lee (1), Chi Ho Lee (2), Wing Sun Chow (2), Alan Chun [...]