학술논문

Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ

Document Type

Report

Author

Tsujimoto, Shunsuke; Kishina, Manabu; Koda, Masahiko; Yamamoto, Yasutaka; Tanaka, Kohei; Harada, Yusuke; Yoshida, Akio; Hisatome, Ichiro

Source

International Journal of Molecular Medicine. September 1, 2016, p721, 8 p.

Subject

Drug therapy
Complications and side effects
Development and progression
Genetic aspects
Patient outcomes
Methods
Obesity -- Complications and side effects
Liver diseases -- Genetic aspects -- Drug therapy -- Development and progression
Molecular targeted therapy -- Methods
Enzyme inhibitors -- Patient outcomes

Language

English

ISSN

1107-3756

Abstract

Abstract. Cyclooxygenase (COX)-2 selective inhibitors suppress non-alcoholic fatty liver disease (NAFLD); however, the precise mechanism of action remains unknown. The aim of this study was to examine how the COX-2 [...]

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