학술논문

PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory
plasminogen activator inhibitor, post-traumatic stress disorder
Document Type
Report
Source
Molecular Psychiatry. September 2021, Vol. 26 Issue 9, p4968, 14 p.
Subject
France
Language
English
ISSN
1359-4184
Abstract
Author(s): C. Bouarab [sup.1] , V. Roullot-Lacarrière [sup.1] , M. Vallée [sup.1] , A. Le Roux [sup.1] , C. Guette [sup.1] , M. Mennesson [sup.1] , A. Marighetto [sup.1] , [...]
Moderate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition. In conditions of moderate stress, glucocorticoid hormones increase the expression of the tPA protein in the hippocampal brain region which by triggering the Erk1/2.sup.MAPK signaling cascade strengthens memory. When stress is particularly intense, very high levels of glucocorticoid hormones then increase the production of PAI-1 protein, which by blocking the activity of tPA induces PTSD-like memories. PAI-1 levels after trauma could be a predictive biomarker of the subsequent appearance of PTSD and pharmacological inhibition of PAI-1 activity a new therapeutic approach to this debilitating condition.