부산대학교 도서관

Background: Emerging scientific evidence has disclosed unsuspected influences between iron metabolism, insulin resistance and type 2 diabetes. Even mildly elevated body iron stores are associated with statistically significant increases in glucose homeostasis indices. But till now high serum ferritin associated with type 2 diabetes is not recognized as an entity in the current clinical guidelines for the management of type 2 diabetes. Methods: This was a Cross sectional study carried out from September 2016 to March, 2017 at PCO clinic of infertility outpatient department (OPD), department of obstetrics and gynecology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study population consisted of all the diagnosed PCOS patients. Purposive sampling Main outcome variable: serum ferritin level and insulin resistance index (Homeostatic model assessment of insulin resistance: HOMA-IR). Results: Most of the (90.9%) patients were aged 20-30 years having BMI >25 kg/[m.sup.2], mostly overweight (52.53%) or obese (25.25%). Significant increase of serum ferritin level (72.89[+ or -]34.97; p=0.001) was noted in PCOS patients with insulin resistance. Marked increase in serum ferritin (82.81[+ or -]31.57, p45.5 ng/ml). Statistically significant strong positive correlation between serum ferritin level and fasting insulin level (r=0.528; p Keywords: Serum ferritin, Insulin resistance, Polycystic ovarian syndrome
INTRODUCTION Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder characterized by hyperandrogenemia, hyperinsulinemia, insulin resistance, and chronic anovulation. It is the most common endocrine disorder in women of [...]