학술논문

Analysis of synergistic and antagonistic effects of TCM: Cases on diabetes and insomnia
Document Type
Conference
Source
2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW) Bioinformatics and Biomedicine Workshops (BIBMW), 2010 IEEE International Conference on. :620-624 Dec, 2010
Subject
Bioengineering
Communication, Networking and Broadcast Technologies
Computing and Processing
General Topics for Engineers
Diabetes
Sugar
Blood
Reliability
Diseases
Limiting
Probability
interactions
synergistic effects
antagonistic effects
diabetes
insomnia
Language
Abstract
Herbal Medicine in Traditional Chinese Medicine (TCM) relies on interactions between ingredients of a prescription. The combination is chosen to promote desirable interactions. Analysing these interactions is important in quantitatively analysing effects of TCM on patient outcomes. The concept of interactions has not been adequately formulated before due to the ambiguity of “interaction” and the need to go beyond traditional quantitative methods for analysis. In this working paper, we present an exploratory analysis of clinical records using an interaction pattern mining approach. We present the most significant interactions found with a summary of clinical significance. Our experimental evaluation confirms this approach is able to detect effective high-order herb-herb interactions in TCM datasets. The interaction mining approach can be a potentially useful technique for discovering interactions not detected by other techniques. The results have implications for better understanding of the mechanisms of action and overall system effects.