학술논문
A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas
Document Type
article
Author
Shai Rosenberg; Iva Simeonova; Franck Bielle; Maite Verreault; Bertille Bance; Isabelle Le Roux; Mailys Daniau; Arun Nadaradjane; Vincent Gleize; Sophie Paris; Yannick Marie; Marine Giry; Marc Polivka; Dominique Figarella-Branger; Marie-Hélène Aubriot-Lorton; Chiara Villa; Alexandre Vasiljevic; Emmanuèle Lechapt-Zalcman; Michel Kalamarides; Ariane Sharif; Karima Mokhtari; Stefano Maria Pagnotta; Antonio Iavarone; Anna Lasorella; Emmanuelle Huillard; Marc Sanson
Source
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Chordoid glioma is a slow growing diencephalic tumor whose mutational landscape is poorly characterized. Here, the authors perform whole-exome and RNA-sequencing and find that 15 of 16 chordoid glioma cases studied harbor the same PRKCA mutation which results in enhanced proliferation.