학술논문
Diminished social motivation in early psychosis is associated with polygenic liability for low vitamin D
Document Type
article
Author
Alex Hatzimanolis; Sarah Tosato; Mirella Ruggeri; Doriana Cristofalo; Leonidas Mantonakis; Lida-Alkisti Xenaki; Stefanos Dimitrakopoulos; Mirjana Selakovic; Stefania Foteli; Ioannis Kosteletos; Ilias Vlachos; Rigas-Filippos Soldatos; Nikos Nianiakas; Irene Ralli; Konstantinos Kollias; Angeliki-Aikaterini Ntigrintaki; Pentagiotissa Stefanatou; Robin M. Murray; Evangelos Vassos; Nikos C. Stefanis
Source
Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)
Subject
Language
English
ISSN
2158-3188
Abstract
Abstract Insufficiency of vitamin D levels often occur in individuals with schizophrenia and first-episode psychosis (FEP). However, it is unknown whether this represents a biological predisposition, or it is essentially driven by illness-related alterations in lifestyle habits. Lower vitamin D has also been associated with adverse neurodevelopmental outcomes and predominant negative psychotic symptoms. This study aimed to investigate the contribution of polygenic risk score for circulating 25-hydroxyvitamin D concentration (PRS-vitD) to symptom presentation among individuals with FEP enrolled in the Athens First-Episode Psychosis Research Study (AthensFEP n = 205) and the Psychosis Incident Cohort Outcome Study (PICOS n = 123). The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale at baseline and follow-up assessments (AthensFEP: 4-weeks follow-up, PICOS: 1-year follow-up). Premorbid intelligence and adjustment domains were also examined as proxy measures of neurodevelopmental deviations. An inverse association between PRS-vitD and severity of negative symptoms, in particular lack of social motivation, was detected in the AthensFEP at baseline (adjusted R 2 = 0.04, p