학술논문
Noninvasive ventilation vs. high-flow nasal cannula oxygen for preoxygenation before intubation in patients with obesity: a post hoc analysis of a randomized controlled trial
Document Type
article
Author
Maeva Rodriguez; Stéphanie Ragot; Rémi Coudroy; Jean-Pierre Quenot; Philippe Vignon; Jean-Marie Forel; Alexandre Demoule; Jean-Paul Mira; Jean-Damien Ricard; Saad Nseir; Gwenhael Colin; Bertrand Pons; Pierre-Eric Danin; Jérome Devaquet; Gwenael Prat; Hamid Merdji; Franck Petitpas; Emmanuel Vivier; Armand Mekontso-Dessap; Mai-Anh Nay; Pierre Asfar; Jean Dellamonica; Laurent Argaud; Stephan Ehrmann; Muriel Fartoukh; Christophe Girault; René Robert; Arnaud W. Thille; Jean-Pierre Frat; REVA Network
Source
Annals of Intensive Care, Vol 11, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2110-5820
Abstract
Abstract Background Critically ill patients with obesity may have an increased risk of difficult intubation and subsequent severe hypoxemia. We hypothesized that pre-oxygenation with noninvasive ventilation before intubation as compared with high-flow nasal cannula oxygen may decrease the risk of severe hypoxemia in patients with obesity. Methods Post hoc subgroup analysis of critically ill patients with obesity (body mass index ≥ 30 kg·m−2) from a multicenter randomized controlled trial comparing preoxygenation with noninvasive ventilation and high-flow nasal oxygen before intubation of patients with acute hypoxemic respiratory failure (PaO2/FiO2 5 points and respiratory primary failure as reason for admission. Conclusions Patients with obesity and acute hypoxemic respiratory failure had an increased risk of severe hypoxemia during intubation procedure as compared to patients without obesity. However, preoxygenation with noninvasive ventilation may not reduce this risk compared with high-flow nasal oxygen. Trial registration Clinical trial number: NCT02668458 ( http://www.clinicaltrials.gov )