학술논문
Associations of Circulating Estrogens and Estrogen Metabolites with Fecal and Oral Microbiome in Postmenopausal Women in the Ghana Breast Health Study
Document Type
article
Author
Zeni Wu; Ruth M. Pfeiffer; Doratha A. Byrd; Yunhu Wan; Daniel Ansong; Joe-Nat Clegg-Lamptey; Beatrice Wiafe-Addai; Lawrence Edusei; Ernest Adjei; Nicholas Titiloye; Florence Dedey; Francis Aitpillah; Joseph Oppong; Verna Vanderpuye; Ernest Osei-Bonsu; Casey L. Dagnall; Kristine Jones; Amy Hutchinson; Belynda D. Hicks; Thomas U. Ahearn; Rob Knight; Richard Biritwum; Joel Yarney; Seth Wiafe; Baffour Awuah; Kofi Nyarko; Montserrat Garcia-Closas; Rashmi Sinha; Jonine D. Figueroa; Louise A. Brinton; Britton Trabert; Emily Vogtmann
Source
Microbiology Spectrum, Vol 11, Iss 4 (2023)
Subject
Language
English
ISSN
2165-0497
Abstract
ABSTRACT The human fecal and oral microbiome may play a role in the etiology of breast cancer through modulation of endogenous estrogen metabolism. This study aimed to investigate associations of circulating estrogens and estrogen metabolites with the fecal and oral microbiome in postmenopausal African women. A total of 117 women with fecal (N = 110) and oral (N = 114) microbiome data measured by 16S rRNA gene sequencing, and estrogens and estrogen metabolites data measured by liquid chromatography tandem mass spectrometry were included. The outcomes were measures of the microbiome and the independent variables were the estrogens and estrogen metabolites. Estrogens and estrogen metabolites were associated with the fecal microbial Shannon index (global P