학술논문
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
Document Type
article
Author
Marta Pradas-Juni; Nils R. Hansmeier; Jenny C. Link; Elena Schmidt; Bjørk Ditlev Larsen; Paul Klemm; Nicola Meola; Hande Topel; Rute Loureiro; Ines Dhaouadi; Christoph A. Kiefer; Robin Schwarzer; Sajjad Khani; Matteo Oliverio; Motoharu Awazawa; Peter Frommolt; Joerg Heeren; Ludger Scheja; Markus Heine; Christoph Dieterich; Hildegard Büning; Ling Yang; Haiming Cao; Dario F. De Jesus; Rohit N. Kulkarni; Branko Zevnik; Simon E. Tröder; Uwe Knippschild; Peter A. Edwards; Richard G. Lee; Masayuki Yamamoto; Igor Ulitsky; Eduardo Fernandez-Rebollo; Thomas Q. de Aguiar Vallim; Jan-Wilhelm Kornfeld
Source
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose metabolism in mice.