학술논문
Study of the effects of nitroquinoline derivatives on Neisseria gonorrhoeae causative agent of the sexually transmitted infection gonorrhea
Document Type
article
Source
Results in Chemistry, Vol 7, Iss , Pp 101481- (2024)
Subject
Language
English
ISSN
2211-7156
Abstract
According to the World Health Organization (WHO), sexually transmitted infection (SI) gonorrhea is now a global public health challenge due to failure of current treatments. Therefore, it is important to develop new agents against drug-resistant N. gonorrhoeae, the causative agent of gonorrhea infection.The aim of the present research was to identify active compounds against STI causing bacteria N. gonorrhoeae, and to investigate their modes of action. Alamar blue assay was used to evaluate the antibacterial activity. Compound-induced alterations were investigated by atomic force and scanning electron microscopies. MICs of nitroquinoline derivatives 5 and 8 were 302.8 and 193.23 µM (54.99, and 49.99 µg/mL, respectively), lower than the MIC of the first line of standard drug, ceftriaxone 450.79 µM ± 1.8 (249.99 µg/mL). Cytotoxicity of compounds were also evaluated in blood media. Nitroquinoline derivatives 5 and 8 were found to be more potent than currently used antibiotics, and thus deserve further investigation.