학술논문
Genomic surveillance of SARS-CoV-2 reveals highest severity and mortality of delta over other variants: evidence from Cameroon
Document Type
article
Author
Joseph Fokam; Rene Ghislain Essomba; Richard Njouom; Marie-Claire A. Okomo; Sara Eyangoh; Celestin Godwe; Bryan Tegomoh; John O. Otshudiema; Julius Nwobegahay; Lucy Ndip; Blaise Akenji; Desire Takou; Mohamed M. M. Moctar; Cleophas Kahtita Mbah; Valantine Ngum Ndze; Martin Maidadi-Foudi; Charles Kouanfack; Sandrine Tonmeu; Dorine Ngono; John Nkengasong; Nicaise Ndembi; Anne-Cecile Z. K. Bissek; Christian Mouangue; Chanceline B. Ndongo; Emilienne Epée; Nadia Mandeng; Sandrine Kamso Belinga; Ahidjo Ayouba; Nicolas Fernandez; Marcel Tongo; Vittorio Colizzi; Gregory-Edie Halle-Ekane; Carlo-Federico Perno; Alexis Ndjolo; Clement B. Ndongmo; Judith Shang; Linda Esso; Oliviera de-Tulio; Moussa Moise Diagne; Yap Boum; Georges A. E. Mballa; Louis R. Njock; Genomic Surveillance Study Group
Source
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract While the SARS-CoV-2 dynamic has been described globally, there is a lack of data from Sub-Saharan Africa. We herein report the dynamics of SARS-CoV-2 lineages from March 2020 to March 2022 in Cameroon. Of the 760 whole-genome sequences successfully generated by the national genomic surveillance network, 74% were viral sub-lineages of origin and non-variants of concern, 15% Delta, 6% Omicron, 3% Alpha and 2% Beta variants. The pandemic was driven by SARS-CoV-2 lineages of origin in wave 1 (16 weeks, 2.3% CFR), the Alpha and Beta variants in wave 2 (21 weeks, 1.6% CFR), Delta variants in wave 3 (11 weeks, 2.0% CFR), and omicron variants in wave 4 (8 weeks, 0.73% CFR), with a declining trend over time (p = 0.01208). Even though SARS-CoV-2 heterogeneity did not seemingly contribute to the breadth of transmission, the viral lineages of origin and especially the Delta variants appeared as drivers of COVID-19 severity in Cameroon.