학술논문
Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters
Document Type
article
Author
Wen Su; Sin Fun Sia; Aaron J. Schmitz; Traci L. Bricker; Tyler N. Starr; Allison J. Greaney; Jackson S. Turner; Bassem M. Mohammed; Zhuoming Liu; Ka Tim Choy; Tamarand L. Darling; Astha Joshi; Ka Man Cheng; Alvina Y. L. Wong; Houda H. Harastani; John M. Nicholls; Sean P. J. Whelan; Jesse D. Bloom; Hui-Ling Yen; Ali H. Ellebedy; Adrianus C. M. Boon
Source
mBio, Vol 12, Iss 5 (2021)
Subject
Language
English
ISSN
2150-7511
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through immunization or passively transferred as therapeutics in the form of convalescent-phase sera or monoclonal antibodies (MAbs).