학술논문
MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network
Document Type
article
Author
Giovanni Battista Migliori; Simon Tiberi; Alimuddin Zumla; Eskild Petersen; Jeremiah Muhwa Chakaya; Christian Wejse; Marcela Muñoz Torrico; Raquel Duarte; Jan Willem Alffenaar; H. Simon Schaaf; Ben J. Marais; Daniela Maria Cirillo; Riccardo Alagna; Adrian Rendon; Emanuele Pontali; Alberto Piubello; José Figueroa; Gabriella Ferlazzo; Alberto García-Basteiro; Rosella Centis; Dina Visca; Lia D’Ambrosio; Giovanni Sotgiu; T. Abu Arkub; O.W. Akkerman; A. Aleksa; E. Belilovski; E. Bernal; F-X. Blanc; M. Boeree; S. Borisov; J. Bruchfeld; J. Cadiñanos Loidi; J.A. Caminero; A.C. Carvalho; J.J. Cebrian Gallardo; Charalampos; E. Danila; L. Davies Forsman; J. Denholm; K. Dheda; R. Diel; S. Diktanas; C. Dobler; M. Enwerem; S. Esposito; N. Escobar Salinas; A. Filippov; B. Formenti; J.M. García García; D. Goletti; R. Gomez Rosso; G. Gualano; P. Isaakidis; A. Kaluzhenina; S. Koirala; L. Kuksa; H. Kunst; Y. Li; C. Magis-Escurra; V. Manfrin; S. Manga; K. Manika; V. Marchese; E. Martínez Robles; A. Maryandyshev; A. Matteelli; A. Mariani; J. Mazza-Stalder; F. Mello; L. Mendoza; A. Mesi; S. Miliauskas; H. Mustafa Hamdan; N. Ndjeka; M. Nieto Marcos; T.H.M. Ottenhoff; D.J. Palmero; F. Palmieri; A. Papavasileiou; M.C. Payen; A. Pontarelli; M. Pretti Dalcolmo; S. Quirós Fernandez; R. Romero; D. Rossato Silva; A.P. Santos; B. Seaworth; M. Sinitsyn; A. Skrahina; I. Solovic; A. Spanevello; M. Tadolini; C. Torres; Z. Udwadia; M. van den Boom; G.V. Volchenkov; A. Yedilbayev; R. Zaleskis; J.P. Zellweger
Source
International Journal of Infectious Diseases, Vol 92, Iss , Pp S15-S25 (2020)
Subject
Language
English
ISSN
1201-9712
Abstract
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts.The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines.After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities. Keywords: MDR-TB, XDR-TB, Diagnosis, Treatment, Prevention, Rehabilitation of sequelae