학술논문
Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses
Document Type
article
Author
Nazlisadat Seyed Khoei; Mazda Jenab; Neil Murphy; Barbara L. Banbury; Robert Carreras-Torres; Vivian Viallon; Tilman Kühn; Bas Bueno-de-Mesquita; Krasimira Aleksandrova; Amanda J. Cross; Elisabete Weiderpass; Magdalena Stepien; Andrew Bulmer; Anne Tjønneland; Marie-Christine Boutron-Ruault; Gianluca Severi; Franck Carbonnel; Verena Katzke; Heiner Boeing; Manuela M. Bergmann; Antonia Trichopoulou; Anna Karakatsani; Georgia Martimianaki; Domenico Palli; Giovanna Tagliabue; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; Guri Skeie; Susana Merino; Catalina Bonet; Miguel Rodríguez-Barranco; Leire Gil; Maria-Dolores Chirlaque; Eva Ardanaz; Robin Myte; Johan Hultdin; Aurora Perez-Cornago; Dagfinn Aune; Konstantinos K. Tsilidis; Demetrius Albanes; John A. Baron; Sonja I. Berndt; Stéphane Bézieau; Hermann Brenner; Peter T. Campbell; Graham Casey; Andrew T. Chan; Jenny Chang-Claude; Stephen J. Chanock; Michelle Cotterchio; Steven Gallinger; Stephen B. Gruber; Robert W. Haile; Jochen Hampe; Michael Hoffmeister; John L. Hopper; Li Hsu; Jeroen R. Huyghe; Mark A. Jenkins; Amit D. Joshi; Ellen Kampman; Susanna C. Larsson; Loic Le Marchand; Christopher I. Li; Li Li; Annika Lindblom; Noralane M. Lindor; Vicente Martín; Victor Moreno; Polly A. Newcomb; Kenneth Offit; Shuji Ogino; Patrick S. Parfrey; Paul D. P. Pharoah; Gad Rennert; Lori C. Sakoda; Clemens Schafmayer; Stephanie L. Schmit; Robert E. Schoen; Martha L. Slattery; Stephen N. Thibodeau; Cornelia M. Ulrich; Franzel J. B. van Duijnhoven; Korbinian Weigl; Stephanie J. Weinstein; Emily White; Alicja Wolk; Michael O. Woods; Anna H. Wu; Xuehong Zhang; Pietro Ferrari; Gabriele Anton; Annette Peters; Ulrike Peters; Marc J. Gunter; Karl-Heinz Wagner; Heinz Freisling
Source
BMC Medicine, Vol 18, Iss 1, Pp 1-15 (2020)
Subject
Language
English
ISSN
1741-7015
Abstract
Abstract Background Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in circulating levels of bilirubin are associated with risk of colorectal cancer (CRC). We decided a priori to perform analyses separately in men and women based on suggestive evidence that associations may differ by sex. Methods In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P