학술논문
Nephrotoxic Medications and Risk Factors of Acute Kidney Injury in Medical Wards: A Single-Center Study
Document Type
article
Author
Source
Saudi Journal of Kidney Diseases and Transplantation, Vol 32, Iss 4, Pp 1118-1127 (2021)
Subject
Language
English
ISSN
1319-2442
Abstract
Acute kidney injury (AKI) is a medical complication that can arise from various causes. This study aimed to determine the incidence of AKI and the predictors for the development of AKI in the medical wards of a tertiary hospital. A prospective cohort study was conducted on patients admitted to the medical wards from November 1 to December 31, 2017. Relevant data were obtained from the electronic hospital information system and medication charts. AKI was defined as an increase in serum creatinine (SCr) by ≥0.3 mg/dL (≥26.5 μmol/L) within 48 h, or increase in SCr to ≥1.5 times baseline, within the last seven days. Fisher’s exact test or Pearson’s Chi-square test was used to determine the association between characteristics of the patients and AKI. Logistic regression was used to determine possible predictors of AKI. A total of 260 patients [mean age 54.7 (19.0) years, 50.8% male] were included. Of these, 23% (n = 60) developed AKI. About 81% (n = 210) of the patients were exposed to nephrotoxic medications. Predictors of AKI were number of comorbidities [adjusted odds ratio (aOR): 4.3; 95% confidence interval (CI): 1.8–10.3; P = 0.001], diuretics (aOR: 2.8; 95% CI: 1.2–6.3; P = 0.015), proton pump inhibitors (aOR: 2.9; 95% CI: 1.4–5.8; P = 0.004), and cephalosporin (aOR: 4.5; 95% CI: 2.2–9.1; P