학술논문
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion
Document Type
article
Author
Source
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
PIK3CA mutations and ARID1A loss co-exist in endometrial neoplasms. Here, the authors show that these co-mutations drive gene expression profiles correlated with differential chromatin accessibility and ARID1A binding in the endometrial epithelium, resulting in partial EMT and myometrial invasion.