학술논문
Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women
Document Type
article
Author
Xiaoliang Wang; Pooja Middha Kapoor; Paul L. Auer; Joe Dennis; Alison M. Dunning; Qin Wang; Michael Lush; Kyriaki Michailidou; Manjeet K. Bolla; Kristan J. Aronson; Rachel A. Murphy; Angela Brooks-Wilson; Derrick G. Lee; Emilie Cordina-Duverger; Pascal Guénel; Thérèse Truong; Claire Mulot; Lauren R. Teras; Alpa V. Patel; Laure Dossus; Rudolf Kaaks; Reiner Hoppe; Wing-Yee Lo; Thomas Brüning; Ute Hamann; Kamila Czene; Marike Gabrielson; Per Hall; Mikael Eriksson; Audrey Jung; Heiko Becher; Fergus J. Couch; Nicole L. Larson; Janet E. Olson; Kathryn J. Ruddy; Graham G. Giles; Robert J. MacInnis; Melissa C. Southey; Loic Le Marchand; Lynne R. Wilkens; Christopher A. Haiman; Håkan Olsson; Annelie Augustinsson; Ute Krüger; Philippe Wagner; Christopher Scott; Stacey J. Winham; Celine M. Vachon; Charles M. Perou; Andrew F. Olshan; Melissa A. Troester; David J. Hunter; Heather A. Eliassen; Rulla M. Tamimi; Kristen Brantley; Irene L. Andrulis; Jonine Figueroa; Stephen J. Chanock; Thomas U. Ahearn; Montserrat García-Closas; Gareth D. Evans; William G. Newman; Elke M. van Veen; Anthony Howell; Alicja Wolk; Niclas Håkansson; Hoda Anton-Culver; Argyrios Ziogas; Michael E. Jones; Nick Orr; Minouk J. Schoemaker; Anthony J. Swerdlow; Cari M. Kitahara; Martha Linet; Ross L. Prentice; Douglas F. Easton; Roger L. Milne; Peter Kraft; Jenny Chang-Claude; Sara Lindström
Source
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully understood. We conducted a genome-wide interaction analysis between MHT use and genetic variants for breast cancer risk in 27,585 cases and 34,785 controls from 26 observational studies. All women were post-menopausal and of European ancestry. Multivariable logistic regression models were used to test for multiplicative interactions between genetic variants and current MHT use. We considered interaction p-values