학술논문
Inhibition of human placental progesterone synthesis by danazol in vitro
Document Type
Article
Author
Source
Fertility and Sterility; September 1983, Vol. 40 Issue: 3 p330-333, 4p
Subject
Language
ISSN
00150282; 15565653
Abstract
In vitro, danazol showed a slight dose-dependent inhibition of the mitochondrial cholesterol side chain cleavage enzyme isolated from early gestational (8th to 12th week of gestation) placenta. In the presence of 100μM danazol, the enzyme activity was 65% of controls. Danazol inhibits dose-dependently the mitochondrial 3β-hydroxysteroid dehydrogenase (I50=3.1μM; Ki=1μM) (noncompetitive inhibition) and the cytoplasmic 20α-hydroxysteroid dehydrogenase (I50=1.4μM; Ki=2.6μM) (competitive inhibition).