학술논문
Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study
Document Type
Article
Author
Ober, Carole; McKennan, Chris G; Magnaye, Kevin M; Altman, Matthew C; Washington, Charles; Stanhope, Catherine; Naughton, Katherine A; Rosasco, Mario G; Bacharier, Leonard B; Billheimer, Dean; Gold, Diane R; Gress, Lisa; Hartert, Tina; Havstad, Suzanne; Khurana Hershey, Gurjit K; Hallmark, Brian; Hogarth, D Kyle; Jackson, Daniel J; Johnson, Christine C; Kattan, Meyer; Lemanske, Robert F; Lynch, Susan V; Mendonca, Eneida A; Miller, Rachel L; Naureckas, Edward T; O'Connor, George T; Seroogy, Christine M; Wegienka, Ganesa; White, Steven R; Wood, Robert A; Wright, Anne L; Zoratti, Edward M; Martinez, Fernando D; Ownby, Dennis; Nicolae, Dan L; Levin, Albert M; Gern, James E; Achten, Niek; Ainsworth, John; Akkerman, Nonna; Anderson, Elizabeth; Anderson, Larry J.; Andrews, Howard; Armagost, Elizabeth; Aubuchon, Mary Ann; Bach, Julia; Bacharier, Leonard; Barnes, Kathrine L.; Barone, Charles; Bauer, Irma; Beamer, Paloma; Becker, Patrice; Bednarek, Alyssa; Bellemore, Stacey; Bendixsen, Casper G.; Biagini Myers, Jocelyn M.; Billheimer, Dean; Billstrand, Christine; Birg, Geraldine; Blocki, Shirley; Bloomberg, Gordon; Bobbitt, Kevin; Bochkov, Yury; Bourgeois, Karen; Boushey, Homer; Brockman-Schneider, Rebecca; Brunwasser, Steven M.; Budrevich, Richard; Burkle, Jeffrey W.; Busse, William; Calatroni, Agustin; Campbell, Janice; Carlson-Dakes, Kirsten; Cassidy-Bushrow, Andrea; Chappell, James D.; Chasman, Deborah; Chipps, Teresa M.; Chirkova, Tatiana; Cole, Deanna; Connolly, Alexandra; Cootauco, Michelle; Cootauco, Michelle; Costello, Kaitlin; Couch, Philip; Coull, Brent; Craven, Mark; Crisafi, Gina; Cruikshank, William; Curtsinger, Kristi; Custovic, Adnan; Das, Suman R.; DaSilva, Douglas; Datta, Soma; Davidson, Brent; De La Ossa, Lydia; DeVries, Mark; Di, Qian; Dixon, Samara; Donnerbauer, Erin; Dorst, Marian; Doyle, Susan; Dresen, Amy; Dupont, William D.; Durrange, Janet; Erickson, Heidi; Evans, Michael D.; Ezell, Jerel; Farnham, Leanna; Filardo-Collins, Roxanne; Finazzo, Salvatore; Flege, Zachary; Fleurat, Conner; Floerke, Heather; Floerke, Dorothy; Foss, Terry; Freie, Angela; Frome, Wayne; Fye, Samantha; Gagalis, Lisa; Gammell, Rebecca; Gangnon, Ronald E.; Ge, James E.; Gebretsadik, Tebeb; Gergen, Peter; Gern, James E.; Gibson, Heike; Gjerasi, Edlira; Gold, Diane R.; Gonzalez, Nicole; Goodman, Kayla; Gress, Lisa; Grindle, Kristine; Groeschen, Taylor; Hallmark, Brian; Halonen, Marilyn; Hart, Jaime; Hartert, Tina V.; Havstad, Suzanne; Heinritz, Patrick; Hensley Alford, Sharon; Herbstman, Julie; Hernandez, Kellie; Hoepner, Lori; Jackson, Daniel J.; Jadhao, Samadhan J.; Jaffee, Katy; James, Peter; Jezioro, Jacqueline; Jimenez Pescador, Marcia; Johnson, Christine C.; Johnson, Tara; Johnson, Camille; Jones, Amelia; Jones, Kyra; Jones, Paul; Jordan, Carolina; Joseph, Christine LM; Kattan, Meyer; Keidel, Kristina; Keifer, Matthew C.; Kelley, Rick; Khurana Hershey, Gurgit K.; Kim, Haejin; Kloog, Itai; Koepel, Tammy Kronenwetter; Koerkenmeier, Clint; Ladick, Laura; Lamm, Carin; Larkin, Emma; Lederman, Howard; Lee-Parritz, Aviva; Leimenstoll, Stephanie; Lemanske, Robert F.; LeMasters, Grace K.; Levin, Albert M.; Levine, Jessica; Liu, Xinhua; Liu, Zhouwen; Lopez, Silvia; Lothrop, Nathan; Lovinsky-Desir, Stephanie; Lukacs, Nicholas; Lynch, Susan; Lynch, Christian; Mann, Erik; Martin, Jennifer; Martin, Lisa; Martinez, Fernando D.; Matsui, Elizabeth; McCauley, Katherine; Mccollum, Megan; McCullough, Judith; McKennon, Chris G.; Meece, Jennifer; Mendonca, Eneida; Mikus, Lance; Miller, Rachel L.; Minton, Patricia; Mitchell, Herman; Moon, Vicki; Moore, Paul E.; Morgan, Wayne; Morgan, Valerie; Morgan, David; Murrison, Liza; Nicholas, Charlotte; Nicolae, Daniel; Nunez, Adam; O'Connor, George; O'Toole, Sharon; Ober, Carole; Olson, Brent F.; Ong, Irene; Osmundson, Sarah; Ownby, Dennis; Pappas, Tressa; Perera, Frederica; Perzanowski, Matthew; Peterson, Edward; Pierce, Marcela; Price-Johnson, Penny; Rajamanickam, Victoria; Ramirez, Judyth; Ray, Kimberly; Renneberg, Megan; Requia, Weeberb; Riley, Kylie; Rivera, Janelle; Rivers, Neisha; Roberg, Kathy; Rogers, Theresa; Rosas-Salazar, Christian; Russell, Pat; Ryan, Patrick H.; Sadovsky, Yoel; Salazar, Lisa; Sampson, Hugh; Sandel, Megan; Schoettler, Nathan; Schwartz, Joel; Scott, Dena; Seroogy, Christine M.; Sharp, Renee; Shilts, Meghan H.; Sigelman, Steve; Singh, Anne Marie; Sitarik, Alexandra; Smartt, Ernestine; Sorkness, Ronald; Sorkness, Christine; Spangenberg, Amber; Sperling, Rhoda; Spies, David; Stern, Debra A.; Stoffel, Brandy; Peebles, R. Stokes; Stouffer, Gina; Strauchman Boyer, Cathey; Suddeuth, Caitlin; Tachinardi, Umberto; Tang, Deliang; Tang, Zhengzheng; Tate, Jena; Taylor, William; Tensing, Krista; Tesson, Elizabeth; Thompson, Kathy; Thompson, Emma; Tisler, Christopher; Togias, Alkis; Turi, Kedir; Turner, Victoria; Tuzova, Marina; VanWormer, Jeffrey J.; Visness, Cynthia M.; Vrtis, Rose; Wahlman, Anthony; Wang, Lena; Wegienka, Ganesa; Wells, Karen; Wentworth-Sheilds, William; Wheatley, Lisa; Whitney, Nitsa; Williams, L. Keoki; Witter, Frank; Wolfe, Christopher; Wood, Robert A.; Woodcroft, Kimberley; Woodward, Kim B.; Wright, Anne L.; Wright, Rosalind; Wu, Pingsheng; Yaeger, Melissa; Yaniv, Perri; Zanobetti, Antonella; Zhang, Shirley; Zook, Patricia; Zoratti, Edward M.
Source
The Lancet Respiratory Medicine; May 2020, Vol. 8 Issue: 5 p482-492, 11p
Subject
Language
ISSN
22132600; 22132619
Abstract
African ancestry is associated with a higher prevalence and greater severity of asthma than European ancestries, yet genetic studies of the most common locus associated with childhood-onset asthma, 17q12–21, in African Americans have been inconclusive. The aim of this study was to leverage both the phenotyping of the Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium, and the reduced linkage disequilibrium in African Americans, to fine map the 17q12–21 locus.