학술논문
Dabigatran etexilate for the treatment of acute venous thromboembolism in children (DIVERSITY): a randomised, controlled, open-label, phase 2b/3, non-inferiority trial
Document Type
Article
Author
Halton, Jacqueline; Brandão, Leonardo R; Luciani, Matteo; Bomgaars, Lisa; Chalmers, Elizabeth; Mitchell, Lesley G; Nurmeev, Ildar; Sharathkumar, Anjali; Svirin, Pavel; Gorbatikov, Kirill; Tartakovsky, Igor; Simetzberger, Monika; Huang, Fenglei; Sun, Zhichao; Kreuzer, Jörg; Gropper, Savion; Reilly, Paul; Brueckmann, Martina; Albisetti, Manuela; Nurmeev, Ildar; Safina, Asiya; Zapletal, Ondrej; Brandão, Leonardo R; Kuhn, Tomas; Votava, Tomas; Felgenhauer, Judy; Sharathkumar, Anjali; Svirin, Pavel; Amid, Ali; Halton, Jacqueline; Gorbatikov, Kirill; Saracco, Paola; Kiss, Csongor; Halimeh, Susan; Reschke, Madlen; Wulff, Beate; David, Michele; Novak, Zbynek; Trunina, Inna; Albisetti, Manuela; Frisk, Tony; Glosli, Heidi; Groll, Andreas; Lvova, Olga; Sasmaz, Ilgen; Sosothikul, Darintr; Zilinskaite, Virginija; Cockrell, Erin; Digtyar, Valeriy; Hadacova, Ivana; Palmu, Sauli; Pawar, Anjali; Annichino Bizzacchi, Joyce Maria; Caliskan, Umran; Celkan, Tiraje; Dmytriiev, Dmytro; Druzgal, Colleen Harkins; Onelda Elena, Graciela; Kattamis, Antonis; Kavakli, Ramazan Kaan; Male, Christoph; Ozdemir, Nihal; Van Damme, An; Zvereva, Tatiana; Aarli, Aanen; Paredes Aguilera, Rogelio Alejandro; Aytac, Selin; Carneiro, Jorge; Chistolini, Antonio; Mazzucconi, Maria Gabriela; Corrales-Medina, Fernando; Couturaud, Francis; Croteau, Stacey E; Trenor III, Cameron; Damgaard, Michael; Dixon, Natalia; Galustyan, Anna; Hak, Jiri; Hoffmann, Marianne; Kupesiz, Alphan; Labarque, Veerle; van Geet, Christel; Lin, Ming-Chih; Fu, Yun-Ching; Loggetto, Sandra; Mondelaers, Veerle; Odri-Komazec, Irena; Revel-Vilk, Shoshana; Sevilla, Julian; Fuzzato Silva, Luciano; Kerr Saraiva, José; Montes Tapia, Fernando Felix; Woods-Swafford, Wendy
Source
The Lancet Haematology; January 2021, Vol. 8 Issue: 1 pe22-e33, 12p
Subject
Language
ISSN
23523026
Abstract
Dabigatran etexilate is a direct oral anticoagulant with potential to overcome the limitations of standard of care in children with venous thromboembolism. The aims of this clinical trial were to study the appropriateness of a paediatric dabigatran dosing algorithm, and the efficacy and safety of dabigatran dosed according to that algorithm versus standard of care in treating children with venous thromboembolism.