학술논문
Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease
Document Type
Article
Author
Source
Neurology (Ovid); February 2005, Vol. 64 Issue: 4 p743-745, 3p
Subject
Language
ISSN
00283878; 1526632X
Abstract
The pathogenic mechanisms underlying Batten disease are unclear. Patients uniformly possess autoantibodies against glutamic acid decarboxylase (GAD) that are predominantly reactive with a region of GAD (amino acids 1 to 20) distinct from subjects with autoimmune type 1 diabetes or stiff-person syndrome. Batten patients did not possess autoantibodies against other type 1 diabetes-associated autoantigens and human leukocyte antigen genotypes revealed no specific associations with this disease.